1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. GPR139

GPR139 (G蛋白偶联受体139)

GPR139 (G protein-coupled receptor 139) is a protein that in humans is encoded by the GPR139 gene. GPR139 is an orphan G-protein–coupled receptor expressed in the central nervous system.

The expression pattern of GPR139 has primarily been studied on the mRNA level and showed expression mainly in the central nervous system.

GPR139 is an orphan receptor identified from bioinformatics analysis of the human genome. GPR139 is thus a potential target for the treatment of Parkinson’s disease, obesity, eating disorders, and/or diabetes.

The GPR139 is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. GPR139 agonists dose-dependently protect primary dopaminergic (DA) neurons against MPP+ toxicity.

GPR139 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-19838
    JNJ-63533054 Agonist 99.94%
    JNJ-63533054 是一种有效的,选择性的,具有口服活性的 GPR139 激动剂,对人 GPR139EC50 为 16 nM。JNJ-63533054 对 GPR139 的选择性高于其他 GPCR,离子通道和转运蛋白。JNJ-63533054 可以穿过血脑屏障 (BBB)。
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