1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. GPR139

GPR139 (G蛋白偶联受体139)

G Protein-Coupled Receptor 139

GPR139 (G protein-coupled receptor 139) is a protein that in humans is encoded by the GPR139 gene. GPR139 is an orphan G-protein–coupled receptor expressed in the central nervous system.

The expression pattern of GPR139 has primarily been studied on the mRNA level and showed expression mainly in the central nervous system.

GPR139 is an orphan receptor identified from bioinformatics analysis of the human genome. GPR139 is thus a potential target for the treatment of Parkinson’s disease, obesity, eating disorders, and/or diabetes.

The GPR139 is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. GPR139 agonists dose-dependently protect primary dopaminergic (DA) neurons against MPP+ toxicity.

GPR139 相关产品 (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19838
    JNJ-63533054 Agonist 99.38%
    JNJ-63533054 是一种有效的,选择性的,具有口服活性的 GPR139 激动剂,对人 GPR139EC50 为 16 nM。JNJ-63533054 对 GPR139 的选择性高于其他 GPCR,离子通道和转运蛋白。JNJ-63533054 可以穿过血脑屏障 (BBB)。
  • HY-132228
    Zelatriazin Agonist 99.63%
    Zelatriazin (TAK-041; NBI-1065846) 是一种有效和选择性的 GPR139 激动剂,EC50 为 22 nM。Zelatriazin 具有研究精神分裂症阴性症状的潜力。是是
  • HY-128057
    NCRW0005-F05 Antagonist ≥99.0%
    NCRW0005-F05 是一种有效的 GPR139 拮抗剂,IC50 为 0.21 μM。NCRW0005-F05 可用于糖尿病、肥胖症和帕金森的研究。
  • HY-101777
    TC-O 9311 Agonist 99.70%
    TC-O 9311 是一种有效的孤儿 G 蛋白偶联受体 139 (GPR139) 激动剂,EC50 值为 39 nM。
    TC-O 9311
  • HY-119168
    LP-471756 Antagonist 99.69%
    LP-471756 是一种有效的 GPR139 拮抗剂,IC50 值为 640 nM。LP-471756 抑制 LP-360924 刺激的 cAMP 产生。
  • HY-149651
    GPR139 agonist-2 Agonist 99.80%
    GPR139 agonist-2 (compound 20a) 是一种有效的 GPR139 激动剂,EC50 为 24.7 nM。GPR139 agonist-2 可挽救小鼠精神分裂症模型的社交互动缺陷并减轻认知缺陷。GPR139 agonist-2 具有用于抗精神分裂症药物研究的潜力。
    GPR139 agonist-2