1. Signaling Pathways
  2. Apoptosis
  3. DAPK

DAPK (死亡相关蛋白激酶)

DAPK (Death-associated protein kinase) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to disease. The DAPk family has been linked to several cell death-related signaling pathways, and functions other than cell death have also been proposed.

DAPK 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-15513
    TC-DAPK 6 Inhibitor
    TC-DAPK 6 是一种有效的ATP竞争性的选择性 DAPK 抑制剂,作用于 DAPK1DAPK3IC50 分别为 69 和 225 nM。
  • HY-15847
    HS38 Inhibitor ≥99.0%
    HS38 是一种高效、选择性的,ATP 竞争性的 DAPK1ZIPK (DAPK3) 抑制剂,Kd 值分别为 300 nM 和 280 nM。HS38 也是 PIM3 的抑制剂,其 IC50 值为 200 nM。HS38 可用于平滑肌相关疾病的研究。
  • HY-P1344A
    DAPK Substrate Peptide TFA 99.33%
    DAPK Substrate Peptide TFA 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物, Km 为 9 μM。
  • HY-122629
    DRAK2-IN-1 Inhibitor
    DRAK2-IN-1,化合物 16,是一种有效的选择性 ATP 竞争性的 DRAK2 抑制剂,IC50Ki 值分别为 3 nM 和 0.26 nM。DRAK2-IN-1 对 DRAK1 具有抑制作用 (IC50=51 nM)。
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