1. Signaling Pathways
  2. Apoptosis
  3. DAPK

DAPK

DAPK (Death-associated protein kinase) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to disease. The DAPk family has been linked to several cell death-related signaling pathways, and functions other than cell death have also been proposed.

DAPK 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15513
    TC-DAPK 6 Inhibitor
    TC-DAPK 6 是一种有效的ATP竞争性的选择性 DAPK 抑制剂,作用于 DAPK1DAPK3IC50 分别为 69 和 225 nM。
  • HY-122629
    DRAK2-IN-1 Inhibitor
    DRAK2-IN-1 是一种有效的选择性 ATP 竞争性的 DRAK2 抑制剂,IC50Ki 值分别为 3 nM 和 0.26 nM。DRAK2-IN-1 对 DRAK1 具有抑制作用 (IC50=51 nM)。
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