1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MAP4K

MAP4K 

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases. MAP4Ks including MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, MAP4K4/HGK, MAP4K5/KHS, and MAP4K6/MINK have been reported to induce JNK activation through activating the MAP3K-MAP2K cascade. MAP4Ks play important roles in the regulation of cell apoptosis, cell survival, cell autophagy, and cell migration. Several studies reported that MAP4Ks are involved in the regulation of immune-cell responses through JNK-independent pathways.

MAP4K1/HPK1 and MAP4K4/HGK play negative roles in T-cell activation and inflammatory responses. In contrast, MAP4K3/GLK plays a positive role in T-cell activation and autoimmune responses. Moreover, MAP4K1 downregulation and MAP4K3 overexpression in T cells are involved in human autoimmune diseases such as psoriatic arthritis, rheumatoid arthritis (RA), adult-onset Still’s disease, and SLE.

MAP4K 亚型特异性产品:

  • MAP4K4/HGK

MAP4K 相关产品 (2):

目录号 产品名 作用方式 纯度
  • HY-19562
    PF-06260933 Inhibitor 98.41%
    PF-06260933 是一种具有口服活性的,高度选择性的 MAP4K4 小分子抑制剂,在激酶实验和细胞实验中的 IC50 值分别为 3.7 和 160 nM。
  • HY-125012
    MAP4K4-IN-3 Inhibitor
    MAP4K4-IN-3 (Compound 17) 是一种有效的选择性 MAP4K4 抑制剂,在激酶实验中 IC50 为 14.9 nM,在细胞实验中 IC50 为 470 nM。具有抗糖尿病活性。
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