1. Signaling Pathways
  2. MAPK/ERK Pathway
    Stem Cell/Wnt
  3. ERK

ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway. In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many transcription factors, such as ELK1, and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf and receptors such as HER2.

ERK Isoform Specific Products:

  • ERK

  • ERK1

  • ERK2

  • ERK5

ERK 相关产品 (53):

Cat. No. Product Name Effect Purity
  • HY-50846
    SCH772984 Inhibitor 99.53%
    SCH772984 有效抑制 ERK1ERK2 活性,IC50 分别为 4 和 1 nM。
  • HY-N0003
    Honokiol Activator 99.90%
    Honokiol是一种具有生物活性的双酚类植物化学物质,靶向多种信号分子,具有有效的抗氧化,抗炎,抗血管生成和抗癌活性。 它抑制 Akt 的活化并增强 ERK1/ERK2 的磷酸化。
  • HY-15947
    Ravoxertinib Inhibitor 99.79%
    Ravoxertinib (GDC-0994) 是可口服的 ERK 激酶抑制剂,抑制 ERK1ERK2IC50 分别为6.1 nM 和 3.1 nM。
  • HY-19696A
    Tauroursodeoxycholate Sodium Inhibitor
    Tauroursodeoxycholate Sodium 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK
  • HY-101494
    LY3214996 Inhibitor 99.87%
    LY3214996 是高效的选择性 ERK1ERK2 抑制剂,IC50 为 5 nM。
  • HY-19696B
    Tauroursodeoxycholate dihydrate Inhibitor
    Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK
  • HY-18285
    Longdaysin Inhibitor 99.92%
    Longdaysin 是 CK1αCK1δCDK7ERK2 抑制剂,其对 CK1α,CK1δ,CDK7,ERK2 的 IC50 值分别为 5.6 µM,8.8 µM,29 µM,52 µM。
  • HY-128341
    ERK5-IN-2 Inhibitor
    ERK5-IN-2 是一种具有口服活性,亚微摩尔效力,选择性的 ERK5 抑制剂,对 ERK5ERK5 MEF2DIC50s 分别是 0.82 μM,3 μM。ERK5-IN-2 不与 BRD4 溴结构域相互作用。ERK5-IN-2 抑制肿瘤异种移植生长和 碱性成纤维细胞生长因子 (bFGF) 驱动的基质胶塞血管的生成。
  • HY-15615A
    TIC10 Inhibitor 99.68%
    TIC10是一种有效,有口服活性,稳定的 TRAIL 诱导剂,其通过抑制 AktERK 起作用,从而激活Foxo3a并显着诱导细胞表面TRAIL。
  • HY-15816
    Ulixertinib Inhibitor 99.87%
    Ulixertinib (BVD-523; VRT752271) 是一种有效、可口服、高度选择性、ATP-竞争性、可逆、共价的 ERK1/2 抑制剂,对 ERK2 的 IC50 值 <0.3 nM。Ulixertinib (BVD-523; VRT752271) 可抑制 ERK2 和 下游蛋白 RSK 的磷酸化。
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
  • HY-104047
    LM22B-10 Activator 98.81%
    LM22B-10 是一种 TrkB/TrkC 神经营养因子受体激活剂,能够诱导体内体外 TrkBTrkCAKTERK 的活化。
  • HY-14443
    XMD8-92 Inhibitor 99.72%
    XMD8-92 是一种选择性的 ERK5/BMK1 抑制剂,Kd 为 80 nM。
  • HY-12275
    FR 180204 Inhibitor 99.60%
    FR 180204 是一种选择性的,ERK 的 ATP 竞争性抑制剂,对 ERK1 和 ERK2 的 Ki 值分别为 0.31 μM 和 0.14 μM。
  • HY-B0185
    Lidocaine Inhibitor 99.52%
    Lidocaine (Lignocaine) 是一种常用的酰胺衍生物局部麻醉剂,一种治疗室性心律失常的药物和有效的肿瘤抑制剂。Lidocaine 通过调节 miR-145 表达和进一步抑制 MEK/ERKNF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 使小鼠在用局部麻醉剂后可导致尾部的热和机械伤害感消失。
  • HY-112082
    BAY885 Inhibitor 99.01%
    BAY885是新颖的 ERK5 抑制剂。
  • HY-14178
    VX-11e Inhibitor 98.68%
    VX-11e 是一种高效的,具有选择性的,可口服的 ERK 抑制剂,Ki 值 < 2 nM。
  • HY-101846
    AX-15836 Inhibitor 98.95%
    AX-15836是有效,选择性的ERK5抑制剂,IC50值为8 nM。
  • HY-10579
    Pluripotin Inhibitor 98.86%
    Pluripotin 是 ERK1RasGAP 的双重抑制剂,KD 分别为 98 nM 和 212 nM。Pluripotin 还抑制 RSK1RSK2RSK3RSK4IC50 分别为 0.5,2.5,3.3 和 10.0 μM。
  • HY-B0185A
    Lidocaine hydrochloride Inhibitor 99.95%
    Lidocaine hydrochloride (Lignocaine hydrochloride) 是一种常用的酰胺衍生物局部麻醉剂,一种治疗室性心律失常的药物和有效的肿瘤抑制剂。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERKNF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine hydrochloride 使小鼠在用局部麻醉剂后可导致尾部的热和机械伤害感消失。
Isoform Specific Products

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