2. 重组蛋白
  3. Enzymes & Regulators
  4. Phosphatase

Phosphatase  (磷酸酶)

磷酸酶是一组水解酶，能催化磷酸单酯的水解，从底物中去除磷酸盐部分。 与使底物磷酸化的激酶不同，磷酸酶使底物去磷酸化。 磷酸化是调节蛋白质功能的一种基本而普遍的机制。 磷酸酶和激酶是细胞内蛋白质可逆磷酸化的调节因子，磷酸化是生物体内信号传导的主要形式，也是生物体内重要的调节机制。 蛋白质磷酸酶是磷酸化蛋白质中水解磷酸酯键的酶。真核蛋白磷酸酶是一种结构和功能多样的酶，由三个不同的基因家族代表，包括 PPPs (磷酸蛋白磷酸酶)、PPMs (金属依赖性蛋白磷酸酶) 和PTPs (蛋白酪氨酸磷酸酶)。 PPPs 和 PPMs使磷酸丝氨酸和磷酸苏氨酸残基去磷酸化，而 PTPs 使磷酸酪氨酸氨基酸去磷酸化。

Phosphatases are a group of hydrolases that catalyze the hydrolysis of a phosphomonoester, removing a phosphate moiety from the substrate. In contrast to kinases, which phosphorylate substrate, phosphatases dephosphorylate the substrate. Phosphorylation is a fundamental and pervasive mechanism widely known to regulate the functions of proteins. Phosphatases and kinases act as regulators of protein reversible phosphorylation in the cell, which constitutes a major form of signaling and an essential mechanism of regulation in all living organisms. Protein phosphatases are the enzymes that hydrolyze phospho-ester bonds in phosphorylated proteins. Eukaryotic protein phosphatases are structurally and functionally diverse enzymes that are represented by three distinct gene families, including the PPPs (phosphoprotein phosphatases), PPMs (metal-dependent protein phosphatases) and PTPs (protein tyrosine phosphatases). PPPs and PPMs dephosphorylate phosphoserine and phosphothreonine residues, whereas the PTPs dephosphorylate phosphotyrosine amino acids.

 
目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度