1. 重组蛋白
  2. Viral Proteins
  3. HPV Proteins

HPV Proteins  (人类乳突病毒蛋白)

Human papillomavirus (HPV) is an infectious human virus of the skin. As most papillomaviruses do, HPV can cause papillomas, or skin lesions. low-risk HPV are much more common than high-risk HPV among humans and often do not cause any symptoms. In fact, only 18 types of HPV pose a cancer risk, mostly for anogenital cancers. Papillomaviruses are small, non-enveloped, icosahedral DNA viruses that have a diameter of 52–55 nm. The viral particles consist of a single double-stranded, circular DNA genome of about 8000 bp that contain approximately eight ORFs. The ORF can be divided into three functional parts: the early (E) region that encodes proteins (E1–E7) necessary for viral replication; the late (L) region that encodes the structural proteins (L1–L2) that are required for virion assembly; and a largely non-coding part that is referred to as the long control region (LCR), which contains cis elements that are necessary for the replication and transcription of viral DNA. The viral E proteins are transcribed from the early promoter (e.g. P97 in HPV 31) whereas the L proteins are transcribed principally from the late promoter (P742 in HPV 31).

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