1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MNK

MNK

Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate the oncogene eIF4E on serine 209. This phosphorylation has been reported to be required for its oncogenic activity. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 in response to mitogens and cellular stress.

MNK Isoform Specific Products:

  • MNK1

  • MNK2

  • MNK

MNK 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-100022
    Tomivosertib Inhibitor 99.49%
    Tomivosertib (eFT508) 是一种口服有效的选择性 MNK1MNK2 抑制剂,IC50 值都为 1-2 nM。Tomivosertib (eFT508) 处理肿瘤细胞,降低 eIF4E 磷酸化 (位点为 Ser209,IC50=2-16 nM)。Tomivosertib (eFT508) 还显著下调 PD-L1 蛋白的丰度。
  • HY-10520
    CGP 57380 Inhibitor 98.48%
    CGP 57380 是一种细胞渗透的吡唑-嘧啶类化合物,为具有选择性的 Mnk1 抑制剂,IC50 值为 2.2 μM,但是对 p38,JNK1,ERK1/2,PKC 或 Src-like 激酶等没有抑制作用。
  • HY-112424
    ETC-206 Inhibitor 99.76%
    ETC-206 是一种选择性 MNK1MNK2 抑制剂,IC50 分别为 64 nM 和 86 nM。
  • HY-112113
    SLV-2436 Inhibitor 98.13%
    SLV-2436 是一种高效且 ATP 竞争性的 MNK1MNK2 抑制剂,IC50 分别为 10.8 nM 和 5.4 nM。
  • HY-16982
    Cercosporamide Inhibitor
    Cercosporamide 是一种高效的 ATP 竞争性 Pkc1 激酶抑制剂,IC50<50 nM,Ki<7 nM。Cercosporamide 是一种独特的 Mnk 抑制剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.