1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Porcupine


Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-13912
    IWP-2 Inhibitor 99.51%
    IWP-2 是 Wnt 加工和分泌的抑制剂,其 IC50 为 27 nM。IWP-2 靶向膜结合的 O-酰基转移酶 porcupine (Porcn),从而阻止关键的 Wnt 配体棕榈糖基化。IWP-2 还是一种具有 ATP 竞争能力的 CK1δ 抑制剂,对于 M82FCK1δIC50 为 40 nM。
  • HY-17545
    LGK974 Inhibitor 99.90%
    LGK974 (WNT974) 是一种有效的,具有口服活性的特异性 Porcupine (PORCN) 抑制剂,IC50 为 0.1 nM。
  • HY-15659
    Wnt-C59 Inhibitor 99.85%
    Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂,IC50 为 74 pM。
  • HY-18988
    ETC-159 Inhibitor ≥98.0%
    ETC-159 (ETC-1922159) 是有效的,具有口服活性的 PORCN 抑制剂。抑制β-catenin报告基因活性的 IC50 值为2.9 nM。
  • HY-15825
    IWP L6 Inhibitor 99.02%
    IWP L6 (Porcn Inhibitor III) 是高活性 Porcn 抑制剂,EC50 为 0.5 nM。
  • HY-100408
    GNF-6231 Inhibitor 99.81%
  • HY-100853
    IWP-O1 Inhibitor 99.61%
    IWP-O1 是一个有效的 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50 值为 80 pM。IWP-O1 抑制 Wnt 蛋白分泌。IWP-O1 能够抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
  • HY-111472
    Porcn-IN-1 Inhibitor 99.92%
    Porcn-IN-1 是有效的 porcupine 抑制剂,IC50 值为 0.5±0.2 nM。