1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Porcupine


Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-17545
    LGK974 Inhibitor 99.74%
    LGK974 (WNT974) 是一种口服有效的特异性 Porcupine (PORCN) 抑制剂,IC50 为 0.1 nM。
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂,IC50 为 74 pM。
  • HY-15825
    IWP L6 Inhibitor 99.78%
    IWP L6是高活性Porcn抑制剂,EC50为0.5 nM。
  • HY-100408
    GNF-6231 Inhibitor 99.83%
  • HY-111472
    Porcn-IN-1 Inhibitor 99.08%
    Porcn-IN-1 是有效的 porcupine 抑制剂,IC50 值为 0.5±0.2 nM。
  • HY-100853
    IWP-O1 Inhibitor 99.15%
    IWP-O1 是一个有效的Porcn 抑制剂,其在L-Wnt-STF 细胞中测得的 EC50 值为 80 pM。能够抑制HeLa细胞中Dvl2/3和LRP6的磷酸化。IWP-O1通过抑制Wnt蛋白的分泌发挥作用。
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