1. Signaling Pathways
  2. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  3. Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species 相关产品 (129):

Cat. No. Product Name Effect Purity
  • HY-D0940
    H2DCFDA 99.82%
    H2DCFDA是可渗透细胞,用于检测细胞内活性氧 (ROS) 的探针。
  • HY-B0215
    Acetylcysteine Inhibitor >98.0%
    Acetylcysteine 是一种粘液溶解剂,可以减少粘液的厚度。Acetylcysteine 是一种 ROS 抑制剂。
  • HY-100116A
    Mitoquinone mesylate >98.0%
    Mitoquinone mesylate是一种基于TPP的线粒体靶向抗氧化剂。
  • HY-13653
    (-)-Epigallocatechin Gallate 99.91%
    (-)-Epigallocatechin Gallate是一种茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。报道显示(-)-Epigallocatechin Gallate可抑制 EGFR 信号传导,从而发挥抗癌作用。(-)-Epigallocatechin Gallate (EGCG) 是谷氨酸脱氢酶 1/2 (GDH1/2GLUD1/2) 抑制剂。
  • HY-B0166
    L-Ascorbic acid 99.89%
    L-抗坏血酸是一种有效的还原剂和抗氧化剂。
  • HY-121026
    DMNQ Activator >99.0%
    DMNQ 是一种氧化还原循环剂,以浓度依赖性方式在细胞内产生超氧化物和过氧化氢。DMNQ 诱导 ROS 增加。
  • HY-111798A
    HO-1-IN-1 hydrochloride 98.93%
    HO-1-IN-1 hydrochloride (Compound 2) 是血红素加氧酶 1 (HO-1) 抑制剂,IC50 为 250 nM。
  • HY-N0575
    Pinocembrin 99.26%
    Pinocembrin ((+)-Pinocoembrin) 是从蜂胶中得到的黄酮类物质,为竞争性的组氨酸脱羧酶 (histidine decarboxylase) 抑制剂,同时为有效的抗过敏剂,具有抗氧化、抗菌、抗炎作用。
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate 是从中草药黄连中分离出来的一种生物碱,常用作抗生素。Berberine chloride hydrate 诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶 (topoisomerase)。抗肿瘤特性。
  • HY-100168
    BAPTA Inhibitor >98.0%
    BAPTA 是一种钙 (calcium) 螯合剂。BAPTA 抑制细胞内活性氧 (ROS) 水平。
  • HY-D0187
    L-Glutathione reduced 99.83%
    L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) 是一种内源性抗氧化剂,能够清除氧自由基。
  • HY-101445
    Trolox 99.53%
    Trolox 是维生素E类似物,是一种强大的抗氧化剂。
  • HY-N0056
    3,5-Dicaffeoylquinic acid 98.71%
    3,5-Dicaffeoylquinic acid是一种具有抗氧化和抗炎活性的天然酚酸。
  • HY-B0166A
    L-Ascorbic acid sodium salt >98.0%
    L-Ascorbic acid sodium salt 是维生素 C 的更可利用的形式,具有抗氧化作用。
  • HY-N0796
    Procyanidin B2 99.40%
    Procyanidin B2 是一种天然黄酮类物质,具有抗肿瘤,抗氧化等作用。
  • HY-13750
    Ebselen 99.58%
    Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。
  • HY-N0105
    Rhein >99.0%
    Rhein 是一种蒽醌类化合物,具有抗炎、抗氧化、抗癌等作用。
  • HY-100599
    Urolithin A 98.06%
    Urolithin A是具有抗氧化和抗增殖作用的鞣花酸的肠代谢物; 抑制T24和Caco-2细胞的生长的IC50值分别为43.9和49 μM。
  • HY-N1412
    1,3-Dicaffeoylquinic acid 99.82%
    1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物,具有抗氧化活性和自由基清除活性。
  • HY-D0937
    Methoxy-PMS 98.14%
    Methoxy-PMS (1-Methoxy PMS; 1-Methoxyphenazine methosulfate) 是一个稳定的电子传递中介。
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