1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Itk

Itk (IL-2诱导的T细胞激酶)

Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk 相关产品 (2):

目录号 产品名 作用方式 纯度
  • HY-128726
    ITK inhibitor 2 Inhibitor
    ITK inhibitor 2 是一种有效的选择性 ITK 抑制剂,IC50值为 2 nM。详细信息请参考专利文献 WO2011065402A1 中的化合物 4。
  • HY-16984
    GNE-4997 Inhibitor
    GNE-4997 是一种有效选择性的白细胞介素 2 诱导的 T 细胞激酶 (ITK) 抑制剂,Ki 为 0.09 nM,GNE-4997 中可溶性元素碱度与靶外抗增殖作用的相关性降低了细胞毒性。
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