1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Itk

Itk

Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-11092
    BMS-509744 Inhibitor
    BMS-509744是有效、选择性的、ATP竞争性的 Itk 激酶抑制剂,IC50值为 19 nM。
  • HY-109078
    Vecabrutinib Inhibitor 99.96%
    Vecabrutinib (SNS-062) 是一种有效的,非共价的 BTKITK 抑制剂,Kd 值分别为 0.3 nM 和 2.2 nM。Vecabrutinib 对 ITKIC50 值为 24 nM。
  • HY-12680
    PRN694 Inhibitor >99.0%
    PRN694 是一种不可逆的,高效选择性的,有效共价结合的白介素 2 诱导细胞激酶 ITK、 静息淋巴细胞激酶 RLK 双重抑制剂,抑制 ITK、RLK 的IC50 分别为 0.3 nM 和 1.4 nM。PRN694 延长靶向停留时间,使效应细胞在体内外持久衰减。
  • HY-108691
    PF-06465469 Inhibitor
    PF-06465469 是 ITK 的共价抑制剂,IC50 值为 2 nM。
  • HY-128726
    ITK inhibitor 2 Inhibitor
    ITK inhibitor 2 是一种有效的选择性 ITK 抑制剂,IC50值为 2 nM。详细信息请参考专利文献 WO2011065402A1 中的化合物 4。
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