1. Signaling Pathways
  2. PROTAC
  3. AUTAC

AUTAC (自噬靶向嵌合体)

Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.

AUTAC 相关产品 (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134640
    AUTAC4 2267315-04-6 99.12%
    AUTAC4 是一种靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC4 下调细胞质蛋白并通过线粒体自噬促进靶向线粒体更新。
    AUTAC4
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