1. Signaling Pathways
  2. PROTAC
  3. AUTACs

AUTACs (自噬靶向嵌合体)

Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.

AUTACs 相关产品 (4):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134640
    AUTAC4 2267315-04-6 99.12%
    AUTAC4 是一种靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC4 下调细胞质蛋白并通过线粒体自噬促进靶向线粒体更新。
    AUTAC4
  • HY-134184
    AUTAC2 2241669-08-7
    AUTAC2 是一种 FKBP12 靶向自噬介导降解体 (AUTAC)。AUTAC2 包含一个 FBnG 和 SLF 部分,其中 SLF 与FKBP12 非共价结合。
    AUTAC2
  • HY-134183
    AUTAC1
    AUTAC1是一种 MetAP2 靶向自噬介导降解体 (AUTAC)。AUTACs 包含一个降解标签和一个弹头确保靶向特异性。AUTAC1 包含一个 FBnG 和一个 Fumagillol 部分。Fumagillol 共价结合到 MetAP2 上。
    AUTAC1
  • HY-129652
    Halo PROTAC 1 2241668-45-9
    Halo PROTAC 1 由 E3 配体与 22 个原子相连的复合分子,连接子的接头为 Halogen 基团。Halo PROTAC 1 通过 PEG 接头连接具有 HaloTag 融合的细胞内蛋白质的活性配体和具有诱导细胞内分子自噬活性的结构而成。Halo PROTAC 1 可以用来合成 AUTAC。
    Halo PROTAC 1
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