1. Signaling Pathways
  2. PROTAC
  3. SNIPER

SNIPER 

Specific and Non-genetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers (SNIPER) is designed to induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins. SNIPER and PROTAC are hybrid molecules composed of two different ligands connected by a linker; one ligand is for a target protein and the other is for E3 ubiquitin ligases. A series of SNIPER(ABL) compounds are synthesized by combination of various inhibitors (e.g. ABL, BRD, AR, ER) and IAP ligands, and the linker is optimized for protein knockdown activity.

SNIPER 相关产品 (7):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111863
    SNIPER(ABL)-047
    SNIPER(ABL)-047,由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 MV-1 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 2 μM。
    SNIPER(ABL)-047
  • HY-111854
    SNIPER(ABL)-015
    SNIPER(ABL)-015,由 GNF5 (ABL 抑制剂) 通过 linker 与 MV-1 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 5μM。
    SNIPER(ABL)-015
  • HY-111872
    SNIPER(ABL)-020 99.44%
    SNIPER(ABL)-020,由 Dasatinib (ABL 抑制剂) 通过 linker 与 Bestatin (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白。
    SNIPER(ABL)-020
  • HY-111858
    SNIPER(ABL)-050
    SNIPER(ABL)-050,由 Imatinib (ABL 抑制剂) 通过 linker 与 MV-1 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白。
    SNIPER(ABL)-050
  • HY-111871
    SNIPER(ABL)-033 2222354-18-7
    SNIPER(ABL)-033,由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 0.3 μM。
    SNIPER(ABL)-033
  • HY-111879
    Biotin-BS
    BzNH-BS 含有两种不同的配体 MeBS 和 biotin。它们通过 linker 连接。MeBS 作为 cIAP1泛素连接酶细胞抑制剂的配体。
    Biotin-BS
  • HY-111860
    SNIPER(ABL)-013
    SNIPER(ABL)-013,由 GNF5 (ABL 抑制剂) 通过 linker 与 Bestatin (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 20 μM。
    SNIPER(ABL)-013
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