2. 重组蛋白
  3. Enzymes & Regulators
  4. Serine/Threonine Kinase Proteins

Serine/Threonine Kinase Proteins  (丝氨酸/苏氨酸蛋白激酶)

蛋白激酶控制新陈代谢、转录、细胞分裂和运动、程序性细胞死亡，并参与免疫反应和神经系统功能。 蛋白磷酸化包括蛋白激酶和磷酸化蛋白磷酸酶的平衡作用，使磷酸化-去磷酸化成为一个整体可逆过程。根据磷酸化蛋白的氨基酸残基，蛋白激酶可分为以下家族：丝氨酸/苏氨酸蛋白激酶、酪氨酸特异性蛋白激酶、组氨酸特异性蛋白激酶、色氨酸激酶、天冬氨酸/谷氨酰基蛋白激酶。 丝氨酸/苏氨酸蛋白激酶是利用 ATP 作为磷酸盐供体，催化目标蛋白上的丝氨酸或苏氨酸残基磷酸化的蛋白激酶。 丝氨酸/苏氨酸蛋白激酶包括周期蛋白依赖激酶、丝裂原活化蛋白激酶 (MAPK)、蛋白激酶 D、nattokinase、DNA 依赖蛋白激酶、Aurora 蛋白激酶、胰腺激肽原酶。

Protein kinases control metabolism, transcription, cell division and movement, programmed cell death, and they participate in the immune response and nervous system function. Protein phosphorylation involves the balanced action of protein kinases and phosphoprotein phosphatases making phosphorylation-dephosphorylation an overall reversible process. According to amino acid residues of proteins that are phosphorylated, the protein kinases are classified into the following families：Serine/threonine protein kinases，Tyrosine-specific protein kinases，Histidine-specific protein kinases，Tryptophan kinase，Aspartyl/glutamyl protein kinase. Serine/threonine protein kinases are protein kinases which catalyze the phosphorylation of serine or threonine residues on target proteins by using ATP as phosphate donor. Serine/threonine protein kinases include cyclin-dependent kinase, mitogen-activated protein kinase (MAPK), protein kinase D, nattokinase, DNA-dependent protein kinase, Aurora protein kinases, pancreatic kininogenase.

 
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