1. Signaling Pathways
  2. Vitamin D Related
  3. VD/VDR

VD/VDR

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR 相关产品 (59):

Cat. No. Product Name Effect Purity
  • HY-10002
    Calcitriol Agonist 99.81%
    Calcitriol 是活性最大的 vitamin D 代谢物,也是 vitamin D 受体 (VDR) 的激动剂。
  • HY-10001
    Calcipotriol Chemical 99.77%
    Calcipotriol 是一种合成的 VitD3 类似物,对 vitamin D 受体具有高亲和力。
  • HY-15398
    Cholecalciferol Activator 99.42%
    Cholecalciferol(Vitamin D3)是维生素D的天然存在形式,代谢激活后能诱导细胞分化和癌细胞增殖。
  • HY-32351A
    Calcifediol monohydrate Inhibitor 99.89%
    Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate) 是由维生素 D3 在肝中经羟基化后得到的前激素,是有效的 VDR 抑制剂。
  • HY-50919
    Paricalcitol Agonist 99.95%
    Paricalcitol 是 vitamin D receptor 的激活剂,用于研究继发性甲状旁腺功能亢进 (分泌过多的甲状旁腺激素),该疾病与慢性肾功能衰竭有关。
  • HY-32339
    Maxacalcitol Activator 99.71%
    Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素D3类似物和VDR样受体的配体。
  • HY-32349
    Ercalcidiol Modulator 98.45%
    Ercalcidiol 是一种 vitamin D2 代谢物,作为 vitamin D 营养状态的指标。
  • HY-32350
    Ercalcitriol Activator 98.17%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。
  • HY-76915
    24, 25-Dihydroxy VD3 Activator 98.20%
    24, 25-Dihydroxy VD3是与1,25-dihydroxyvitamin D3紧密相关的化合物,是维生素D3的活性形式。
  • HY-75958
    Vitamin D4 Activator 98.79%
    Vitamin D4是维生素D的活性类似物。
  • HY-32351
    Calcifediol Inhibitor 98.93%
    Calcifediol (25-hydroxy Vitamin D3) 是由维生素 D3 在肝中经羟基化后得到的前激素,是有效的 VDR 抑制剂。
  • HY-76801
    24, 25-Dihydroxy VD2 Activator 99.79%
    24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物,是合成的维生素D类似物。
  • HY-32341
    Seocalcitol Agonist 99.15%
    Seocalcitol 是一种 vitamin D 类似物,作用于人骨肉瘤 MG-63 细胞,结合 vitamin D 受体蛋白,Kd 为 0.27 nM。
  • HY-76542
    Vitamin D2 Activator 99.53%
    Vitamin D2 (Ergocalciferol)是维生素D的一种形式, 通过类固醇的光化学键断裂形成的, 可用作维生素D补充剂。
  • HY-32343
    Secalciferol Activator 98.58%
    Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。
  • HY-10003
    Alfacalcidol Activator 99.93%
    Alfacalcidol (1-hydroxycholecalciferol) 是一种维生素 D3 的衍生物,是非选择性的维生素 D 受体 (VDR) 活化剂,有潜力用于骨质疏松的研究。
  • HY-10001A
    Calcipotriol monohydrate Activator 99.75%
    Calcipotriol是1,25-Dihydroxyvitamin D3类似物,可作用于银屑病。
  • HY-A0020
    Eldecalcitol Activator 99.01%
    Eldecalcitol (ED-71) 是一种具有口服活性维生素 D 类似物,用于骨质疏松症的研究。Eldecalcitol 对骨吸收有很强的抑制作用,使骨密度显著增加。
  • HY-32348
    Doxercalciferol Activator 99.85%
    Doxercalciferol 是维生素 D2 类似物,为维生素 D (Vitamin D) 受体激活剂,能够抵抗肾病的进程。
  • HY-15254
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Chemical 98.71%
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 是一种Vitamin D3 衍生物。
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