1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Cyclin G-associated Kinase (GAK)

Cyclin G-associated Kinase (GAK) (细胞周期蛋白G相关激酶)

Cyclin G-associated kinase (GAK), also known as auxilin 2, is a cellular serine/threonine kinase. GAK was originally identified as an association partner of cyclin G and CDK5 (cyclin-dependent kinase 5). It is essential for clathrin trafficking, mediating binding of clathrin to the plasma membrane and the trans-Golgi network, and regulating receptor signalling by influencing trafficking downstream of clathrin-coated vesicles. GAK has been reported to phosphorylate the μ2 subunit of adaptor protein 1 and 2 (AP-1 and AP-2), thereby initiating a conformational change and enhancing their binding to sorting signals (in the form of tyrosineor dileucine-based motifs) within the cargo. In addition to its role in the cytoplasm, GAK has important functions in the nucleus. It is required for the maintenance of proper centrosome maturation and progression through mitosis. GAK plays a central role during development and GAK KO mice die early in gestation.

Cyclin G-associated Kinase (GAK) 相关产品 (2):

目录号 产品名 作用方式 纯度
  • HY-117626
    LP-935509 Inhibitor 99.74%
    LP-935509 是一种口服有效的、选择性的、ATP 竞争性的和可透过血脑屏障的一种接头蛋白-2 相关激酶 1 (AAK1) 抑制剂,其 IC50 为 3.3 nM,Ki 为 0.9 nM。LP-935509 也是 BIKE 的有效抑制剂 (IC50=14 nM) 和GAK的中度抑制剂 (IC50=320 nM)。LP-935509 具有镇痛活性。LP-935509可用于神经性疼痛和 SARS-CoV-2 的研究。
  • HY-147258
    Culmerciclib Inhibitor
    Culmerciclib 是一种 细胞周期蛋白依赖的激酶(CDK)抑制剂,具有抗肿瘤活性。
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