1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MAP3K


MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

MAP3K Isoform Specific Products:

  • MAP3K5/ASK1

  • MAP3K7/TAK1

MAP3K 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-103490
    Takinib Inhibitor 98.00%
    Takinib 是一种有效且有选择性的 TAK1 抑制剂,其 IC50 值为 9.5 nM,Takinib 抑制自身磷酸化和非磷酸化 TAK1,其结合在 ATP结合口袋内并通过减慢 TAK1 活化的限速步骤来抑制。
  • HY-18938
    Selonsertib Inhibitor 99.12%
    Selonsertib是一种选择性的,具有生物口服可利用的凋亡信号调节激酶1 (ASK1) 抑制剂,pIC50 为 8.3。
  • HY-15434
    NG25 Inhibitor 99.45%
    NG25 是一种 TAK1MAP4K2 的双抑制剂,IC50 值分别为 149 nM 和 21.7 nM。
  • HY-12686
    5Z-7-Oxozeaenol Inhibitor >99.0%
    5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物,为有效的,不可逆的,选择性的 TAK1VEGF-R2 抑制剂,IC50 值分别为 8 nM 和 52 nM。
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.22%
    Cot 抑制剂-2是COT/Tpl2抑制剂。
  • HY-12947
    GNE-3511 Inhibitor 99.98%
    GNE-3511是双亮氨酸拉链激酶 (DLK)抑制剂,Ki为0.5 nM。
  • HY-100844
    GS-444217 Inhibitor 99.80%
    GS-444217 是一种有效的,可口服的,选择性 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 2.87 nM。
  • HY-19566
    NQDI-1 Inhibitor
    NQDI-1 抑制凋亡信号调节激酶 1 (ASK1),Ki 为 500 nM,IC50 为 3 μM。
  • HY-114331
    DLK-IN-1 Inhibitor 99.47%
    DLK-IN-1 是具有口服活性的双亮氨酸拉链激酶 (DLK, MAP3K12) 的选择性抑制剂,其Ki 值为 3 nM。DLK-IN-1 保持着良好的中枢神经系统穿透能力,并且在脑内剂量过量后依旧耐受性良好,在阿尔兹海默症动物模型中有良好的活性。
  • HY-77251
    TAK1/MAP4K2 inhibitor 1 Inhibitor 99.70%
    TAK1/MAP4K2 inhibitor 1 是一种 TAK1MAP4K2 的双重抑制剂,IC50 值分别为 41.1 nM 和 18.2 nM。
  • HY-32015
    Cot inhibitor-1 Inhibitor
    Cot 抑制剂-1是COT/Tpl2抑制剂。
  • HY-114332
    GNE-8505 Inhibitor
    GNE-8505 是一种口服有效的双亮氨酸拉链激酶 (DLK) 抑制剂。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.