2. Signaling Pathways
  3. Epigenetics
  4. DNA Glycosylase

DNA Glycosylase 

DNA Glycosylase

The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. DNA glycosylases play a key role in the elimination of such DNA lesions; they recognize and excise damaged bases, thereby initiating a repair process that restores the regular DNA structure with high accuracy. All glycosylases share a common mode of action for damage recognition; they flip bases out of the DNA helix into a selective active site pocket, the architecture of which permits a sensitive detection of even minor base irregularities. Accordingly, cells lacking DNA glycosylase functions generally show increased levels of base damage in their DNA, elevated mutation rates, and hypersensitivity to specific DNA damaging agents[1][2][3].

DNA Glycosylase 相关产品 (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125276
    TH5487 Inhibitor 98.76%
    TH5487 是一种有效的 8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 抑制剂，IC50 为342 nM，TH5487 阻止 OGG1 识别其 DNA 底物，抑制 DNA 修复和修饰 OGG1 染色质动力学，从而抑制促炎基因。
    TH5487
  • HY-E70578
    T4 Endonuclease V
    T4 Endonuclease V 是一种双活性 DNA 糖基化酶，兼具 DNA N-糖基化酶和 AP 裂解酶的活性。T4 Endonuclease V 可以修复紫外线 (UV) 诱导的 DNA 环丁烷嘧啶二聚体。
    T4 Endonuclease V
  • HY-E70575
    Endonuclease VIII
    Endonuclease VIII 是一种 DNA 修复酶，可切除 DNA 上的氧化嘧啶。Endonuclease VIII 是一种细菌 DNA 糖基化酶/AP 裂解酶，可切除修饰的嘧啶，包括胸腺嘧啶二醇 (Tg)、尿嘧啶二醇、二氢胸腺嘧啶、二氢尿嘧啶 (DHU)。
    Endonuclease VIII
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