2. 重组蛋白
  3. CD Antigens
  4. Macrophage CD Proteins

Macrophage CD Proteins  (巨噬细胞 CD 蛋白)

The cluster of differentiation (CD) antigens a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. CD proteins play a variety of roles in immune system function. Macrophages are large, specialized cells that recognize, engulf and destroy target cells. They are the major myeloid component of mononuclear phagocytes of the innate immune system. In human and mouse, common cell surface markers used to identify macrophages include CD11b/Integrin alpha M, CD14, CD68, Fc gamma RIII/CD16, Fc gamma RI/CD64, and CCR5, along with F4/80 in mouse.

 
目录号 产品名 / 同用名 种属 表达系统
  • HY-P73499
    CD40 Protein, Human (193a.a, HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily member 5; Bp50; CD40L Receptor; CDw40; TNFRSF5

    		Human HEK293
  • HY-P73716
    PD-L1 Protein, Mouse (HEK293, His-Fc)

    Programmed cell death 1 ligand 1; PD-L1; B7-H1; CD274; PDL1

    		Mouse HEK293
  • HY-P70632
    PD-L1 Protein, Mouse (HEK293, His)

    Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274

    		Mouse HEK293
  • HY-P7395
    PD-1 Protein, Human (CHO, Fc)

    重组人PD-1, Fc Chimera (CHO 表达)

    rHuPD-1, Fc Chimera; PD1; CD279; PDCD1

    		Human CHO
    PD-1 Protein, Human (CHO, Fc)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。
  • HY-P70633
    PD-L1 Protein, Mouse (220a.a, HEK293, Fc)

    Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274;

    		Mouse HEK293
  • HY-P7396
    PD-1 Protein, Human (143a.a, HEK293, His)

    重组人 PD-1, His (HEK293 表达)

    rHuPD-1, His; PD1; CD279; PDCD1

    		Human HEK293
    PD-1 Protein, Human (143a.a, HEK293, His)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。
  • HY-P70808
    CD40L/CD154/TRAP Protein, Mouse (HEK293, His)

    重组小鼠 CD40L/CD154/TRAP 蛋白 (HEK293, His)

    CD40 Ligand; CD40LG; HIGM1; T-B cell-activating molecule; T-BAM; TNFSF5; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5

    		Mouse HEK293
    CD40L (CD154; TRAP) 是 CD40 (TNFRSF5) 的配体，在 T 细胞中产生共刺激信号而发挥上调 IL-4 合成的作用。CD40L 在活化的 CD4+ T 淋巴细胞上特异性表达，参与 NF-κB/MAPK 信号通路。CD40L 还参与 B 细胞的分化、成熟和凋亡。小鼠中 CD40L 蛋白可裂解为 2 种亚型，包括膜状肽 (1-260 a.a.) 和可溶性肽 (112-260 a.a.) (作为整合素的配体)。重组小鼠 CD40L/CD154/TRAP 蛋白 (HEK293, His) 全长 149 个氨基酸 (M112-L260)，由 HEK293 细胞表达，带有 N 端 6*His 标签。
  • HY-P7398
    PD-L1 Protein, Human (HEK293, His)

    重组人 PD-L1, His (HEK293 表达)

    rHuPD-L1, His; Programmed death ligand 1; CD274; B7-H1

    		Human HEK293
    PD-L1 Protein, Human (HEK293, His)在妊娠、组织移植、自身免疫性疾病和肝炎等疾病状态下，对免疫系统的适应性起着重要的抑制作用。
  • HY-P7003
    BAFF/TNFSF13B Protein, Human (CHO)

    重组人 B 细胞激活因子/TNFSF13B (CHO 细胞表达)

    rHuBAFF/TNFSF13B; BLYS; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

    		Human CHO
    BAFF/TNFSF13B Protein, Human (CHO)是肿瘤坏死因子超家族的一员，在外周 B 细胞内稳态中具有重要作用。
  • HY-P70807
    PVR/CD155 Protein, Human (HEK 293, His)

    Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS

    		Human HEK293
    PVR/CD155 Protein, Human (HEK 293, His)是一种在 HEK 293 细胞中表达的，N 末端有 His 标签的重组人PVR。PVR, Human 在癌细胞的侵袭和迁移中起作用。
  • HY-P70824
    CD3 epsilon Protein, Human (27a.a, HEK293, Fc)

    T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e; CD3E; T3E

    		Human HEK293
  • HY-P72022
    SLAMF2/CD48 Protein, Human (194a.a, HEK293, hFc)

    B-lymphocyte activation marker BLAST-1 BCM1 surface antigen; Leukocyte antigen MEM-102; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; TCT.1; CD48; BCM1; BLAST1;

    		Human HEK293
  • HY-P7399
    PD-L2 Protein, Human (HEK293, Fc)

    重组人 PD-L2，Fc 嵌合体 (HEK293 表达)

    rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273

    		Human HEK293
    PD-L2 Protein, Human (HEK293, Fc)是 PD-1 的另一个配体，和PD-1相互作用，负调控T细胞增殖，细胞因子的产生和细胞毒性。
  • HY-P73682
    RANK L/TNFSF11 Protein, Human (HEK293, Fc)

    重组人 RANKL/TNFSF11 蛋白 (HEK293, Fc)

    Tumor necrosis factor ligand superfamily member 11; ODF; RANKL; CD254; TNFSF11

    		Human HEK293
    RANKL (TNFSF11)，一种 II 型跨膜蛋白，是 NF-κB (RANK) 受体的配体。RANKL 是 NF-κB 的激活剂。当与 NF-κB 结合后，其诱导单核细胞/巨噬细胞谱系细胞分化为破骨细胞，并进一步导致破骨细胞前体成熟。因此，RANKL 对于破骨细胞成熟、骨骼建模和骨骼重塑，以及淋巴结 (LN) 的发育至关重要。RANKL/TNFSF11 Protein, Human (HEK293, Fc) 是一种由 HEK293 产生的重组人RANKL (G63-D244)，N 端带 mFc 标签。
  • HY-P70010
    CD73/5'-Nucleotidase Protein, Human (521a.a, HEK293, His)

    rHu5'-nucleotidase/CD73, His; 5'-Nucleotidase; 5'-NT; Ecto-5'-Nucleotidase; CD73; NT5E; NT5; NTE

    		Human HEK293
  • HY-P70325
    IL-4R alpha/CD124 Protein, Human (HEK293, mFc)

    重组人 (HEK293, mFc) 白介素-4 受体 alpha/CD124

    rHuInterleukin-4 receptor subunit alpha/IL-4 RA, mFc; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA

    		Human HEK293
    IL-4R alpha 是 IL-4 和 IL-13 受体共有的 α 亚基，最初发现于白细胞中。IL-4R alpha 耦连于 JAK1/2/3-STAT6 通路，参与促进 Th2 分化。IL-4R alpha/CD124, Human 由 825 个氨基酸 (M1-S825) 组成，存在跨膜结构域 (233-256 a.a) 和可溶性形式 (1-227 a.a)。可溶性 IL-4R (sIL-4R) 可抑制 IL-4 介导的细胞增殖和 T 细胞对 IL-5 的上调。IL-4R alpha/CD124, Human (M26-Q231) 在 HEK293 细胞中产生，带有 C- 末端 mFc 标记。
  • HY-P70428
    BAFF/TNFSF13B Protein, Human (HEK293, His)

    重组人 BAFF/TNFSF13B 蛋白 (HEK293, His)

    Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1

    		Human HEK293
    BAFF/TNFSF13B，是激活B细胞的细胞因子，属于肿瘤坏死因子家族。BAFF 参与癌症免疫，主要在髓系细胞中表达。它的过度表达可导致自身免疫，如系统性红斑狼疮 (SLE)。此外，BAFF 还参与了脂肪形成、动脉粥样硬化、神经炎症过程和缺血再灌注 (I/R) 损伤。人的 BAFF 蛋白有 2 个糖基化结构域和 1 个跨膜结构域 (48-68 a.a.)，可裂分为膜型肽片段和可溶性肽片段。重组人 BAFF/TNFSF13B 蛋白 (HEK293, Fc) 是 BAFF 蛋白的胞外部分 (A134-L285)，由 HEK293 细胞表达，带有 N 端 6*His 标签。
  • HY-P70490
    Fc gamma RIIIA/CD16a Protein, Human (F176V, HEK293, His)

    Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3

    		Human HEK293
  • HY-P70506
    CD3 epsilon Protein, Human (HEK293, His)

    T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e; CD3E; T3E

    		Human HEK293
  • HY-P70525
    PD-1 Protein, Human (HEK293, mFc)

    Programmed cell death protein 1; hPD-1; PDCD1; CD279

    		Human HEK293
目录号 产品名 作用方式 纯度