1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aminopeptidase

Aminopeptidase (氨肽酶)

Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates. Regarding catalytic mechanism, most of the aminopeptidases are metallo-enzymes but cysteine and serine peptidases are also included in this group. Aminopeptidases are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Several aminopeptidases perform essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes and are inhibited by the transition-state analog bestatin. Some are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits.

Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response.

Aminopeptidase 相关产品 (16):

目录号 产品名 作用方式 纯度
  • HY-15695
    Puromycin aminonucleoside Inhibitor ≥98.0%
    Puromycin aminonucleoside (NSC 3056) 是一种氨基核苷类抗生素,为嘌呤霉素类似物。Puromycin aminonucleoside 诱导细胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞浆丙氨酸氨基肽酶。
  • HY-B0134
    Bestatin Inhibitor
    Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-14807
    Tosedostat Inhibitor 99.75%
    Tosedostat (CHR-2797) 是一种具有口服活性氨基肽酶 (aminopeptidase) 抑制剂。CHR-2797 对多种肿瘤细胞系均具有抗增殖作用。
  • HY-113952
    Actinonin Inhibitor ≥98.0%
    Actinonin ((-)-Actinonin) 是一种由放线菌产生的天然抗菌剂。Actinonin 抑制氨肽酶 M,氨肽酶 N 和亮氨酸氨肽酶。Actinonin 是一种有效的可逆肽去甲酰基酶 (PDF) 抑制剂,Ki 为 0.28 nM。Actinonin 还抑制 MMP-1MMP-3MMP-8MMP-9hmeprin αKi 值分别为 300 nM,1,700 nM,190 nM,330 nM 和 20 nM。Actinonin 是一种凋亡诱导剂,具有抗增殖和抗肿瘤活性。
  • HY-B0134A
    Bestatin hydrochloride Inhibitor 99.17%
    Bestatin hydrochloride (Ubenimex hydrochloride) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-14807S
    Tosedostat-d5 Inhibitor
    Tosedostat-d5 (CHR-2797-d5) 是 Tosedostat 的氘代物。Tosedostat (CHR-2797) 是一种具有口服活性氨基肽酶 (aminopeptidase) 抑制剂。CHR-2797 对多种肿瘤细胞系均具有抗增殖作用。
  • HY-101932
    TNP-470 Inhibitor ≥99.0%
    TNP-470 是甲硫氨酸氨肽酶-2 抑制剂,也是一种血管生成抑制剂。
  • HY-110259
    HFI-142 Inhibitor ≥99.0%
    HFI-142 是胰岛素调节性氨基肽酶 (IRAP) 抑制剂,Ki 值为 2.01 μM。
  • HY-137298
    LTA4H-IN-1 Inhibitor 98.88%
    LTA4H-IN-1 是一种有效的白三烯 A4 水解酶 LTA4H 抑制剂,IC50 值为 2 nM。LTA4H-IN-1 可用于研究炎症和自身免疫性疾病。详细信息请参考专利文献 WO2015092740A1 中的化合物 29。
  • HY-109058
    Firibastat Inhibitor ≥98.0%
    Firibastat (QGC001) 是一种口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A (APA) 抑制剂 (Ki=200 nM),选择性和特异性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,并降低血压。
  • HY-17625
    Acebilustat Inhibitor 99.72%
    Acebilustat (CTX-4430) 是一种可口服的白三烯 A4 水解酶抑制剂,用于炎症研究。
  • HY-10825
    DG051 Inhibitor 99.76%
    DG051 是一种有效的白三烯 A4 水解酶 (leukotriene A4 hydrolase) 抑制剂,IC50 为 47 nM。
  • HY-115194
    Amastatin hydrochloride Inhibitor
    Amastatin hydrochloride 是一种缓慢,紧密结合的竞争性氨肽酶 (AP) 抑制剂,对气单胞菌氨肽酶,胞质亮氨酸氨肽酶,微粒体氨肽酶的 Ki 值分别为 0.26 nM,30 nM,52 nM。
  • HY-B0134B
    Bestatin trifluoroacetate Inhibitor
    Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-W004291
    Methyl arachidate Inhibitor ≥98.0%
    Methyl arachidate (Methyl eicosanoate) 是一种天然化合物,是一种白三烯 A4 水解酶 (LTA4H) 抑制剂。
  • HY-P1043A
    NGR peptide Trifluoroacetate ≥98.0%
    NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
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