1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aminopeptidase

Aminopeptidase (氨肽酶)

Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein (N-terminus) or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc Metalloenzymes. Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. CDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding. One important aminopeptidase is a zinc-dependent enzyme produced and secreted by glands of the small intestine. It helps the enzymatic digestion of proteins. Additional digestive enzymes produced by these glands include dipeptidases, maltase, sucrase, lactase, and enterokinase.

Aminopeptidase 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-15695
    Puromycin aminonucleoside Inhibitor ≥98.0%
    Puromycin aminonucleoside (NSC 3056) 是一种氨基核苷类抗生素,为嘌呤霉素类似物。Puromycin aminonucleoside 诱导细胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞浆丙氨酸氨基肽酶。
  • HY-B0134
    Bestatin Inhibitor
    Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-14807
    Tosedostat Inhibitor 99.75%
    Tosedostat (CHR-2797) 是一种具有口服活性氨基肽酶 (aminopeptidase) 抑制剂。CHR-2797 对多种肿瘤细胞系均具有抗增殖作用。
  • HY-B0134A
    Bestatin hydrochloride Inhibitor 99.17%
    Bestatin hydrochloride (Ubenimex hydrochloride) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-113952
    Actinonin Inhibitor ≥98.0%
    Actinonin ((-)-Actinonin) 是一种由放线菌产生的天然抗菌剂。Actinonin 抑制氨肽酶 M,氨肽酶 N 和亮氨酸氨肽酶。Actinonin 是一种有效的可逆肽去甲酰基酶 (PDF) 抑制剂,Ki 为 0.28 nM。Actinonin 还抑制 MMP-1MMP-3MMP-8MMP-9hmeprin αKi 值分别为 300 nM,1,700 nM,190 nM,330 nM 和 20 nM。Actinonin 是一种凋亡诱导剂,具有抗增殖和抗肿瘤活性。
  • HY-101932
    TNP-470 Inhibitor ≥99.0%
    TNP-470 是甲硫氨酸氨肽酶-2 抑制剂,也是一种血管生成抑制剂。
  • HY-115194
    Amastatin hydrochloride Inhibitor
    Amastatin hydrochloride 是一种缓慢,紧密结合的竞争性氨肽酶 (AP) 抑制剂,对气单胞菌氨肽酶,胞质亮氨酸氨肽酶,微粒体氨肽酶的 Ki 值分别为 0.26 nM,30 nM,52 nM。
  • HY-B0134B
    Bestatin trifluoroacetate Inhibitor
    Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症研究。
  • HY-P1043A
    NGR peptide Trifluoroacetate ≥98.0%
    NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
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