1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aminopeptidase


Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein (N-terminus) or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc Metalloenzymes. Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. CDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding. One important aminopeptidase is a zinc-dependent enzyme produced and secreted by glands of the small intestine. It helps the enzymatic digestion of proteins. Additional digestive enzymes produced by these glands include dipeptidases, maltase, sucrase, lactase, and enterokinase.

Aminopeptidase 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-B0134
    Bestatin Inhibitor 99.97%
  • HY-14807
    Tosedostat Inhibitor 99.65%
    Tosedostat 是一个氨肽酶抑制剂。
  • HY-10825
    DG051 Inhibitor 99.76%
    DG051 是一种有效的白三烯 A4 水解酶 (leukotriene A4 hydrolase) 抑制剂,IC50 为 47 nM。
  • HY-B0134A
    Bestatin hydrochloride Inhibitor
    Bestatin hydrochloride 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症治疗。
  • HY-B0134B
    Bestatin trifluoroacetate Inhibitor
    Bestatin trifluoroacetate 是 CD13 (Aminopeptidase N)/APNleukotriene A4 hydrolase 抑制剂,常用于癌症治疗。
  • HY-110259
    HFI-142 Inhibitor >99.0%
    HFI-142 是胰岛素调节性氨基肽酶 (IRAP) 抑制剂,Ki 值为 2.01 μM。
  • HY-P1043A
    NGR peptide Trifluoroacetate 98.55%
    NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
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