2. 重组蛋白
  3. Receptor Proteins
  4. Pattern Recognition Receptors

Pattern Recognition Receptors  (模式识别受体)

Pattern Recognition Receptors (PRRs) are a class of receptors capable of recognizing molecules frequently associated with pathogens (Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns—DAMPs). PRRs bridge nonspecific immunity and specific immunity. PRRs recognize and bind their respective ligands and recruit adaptor molecules through their effector domains, initiating downstream signaling pathways to produce nonspecific anti-infection, antitumor, and other immunoprotective effects. Based on protein domain homology, PRRs can be divided in to five types: Toll-like receptors (TLRs), nucleotide oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), C-type lectin receptors (CLRs), and absent in melanoma-2 (AIM2)-like receptors (ALRs).

 
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