1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. ALK

ALK (间变性淋巴瘤激酶)

ALK (Anaplastic lymphoma kinase) is encoded by the ALK gene. ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance. ALK is a dependence receptor, which may exert antagonist functions, proapoptotic or antiapoptotic, depending on the absence or presence of a ligand. Dependence receptors have a potential role in cancer and development. Ligands available for this demonstration were agonist anti-ALK antibodies. ALK is still an orphan receptor, given the high level of controversy about pleiotrophin and midkine.

ALK 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-10432
    A 83-01 Inhibitor >98.0%
    A 83-01 是一种有效的 TGF-β I 型受体 ALK5ALK4ALK7 的抑制剂,能够抑制 ALK5ALK4ALK7 诱导的转录,IC50 值分别为 12 nM,45 nM 和 7.5 nM。
  • HY-10432A
    A 83-01 sodium salt Inhibitor
    A 83-01 sodium salt 是一种有效的 TGF-β I 型受体 ALK5ALK4ALK7 的抑制剂,能够抑制 ALK5ALK4ALK7 诱导的转录,IC50 值分别为 12 nM,45 nM 和 7.5 nM。
  • HY-15609
    AZD-3463 Inhibitor 99.96%
    AZD-3463 (ALK/IGF1R inhibitor) 是一种具有口服活性的 ALK/IGF1R 抑制剂,对 ALK 作用的 Ki 值为 0.75 nM。AZD-3463 可诱导神经母细胞瘤细胞凋亡 (apoptosis) 和自噬 (autophagy)。
  • HY-15357
    ALK inhibitor 1 Inhibitor 99.71%
    ALK inhibitor 1 (compound 17) 是一种有效的,嘧啶类 ALK 抑制剂。ALK inhibitor 1 是有效的睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2; IC50=31 nM) 和粘着斑激酶 (FAK; IC50=2 nM) 抑制剂。
  • HY-16590
    X-376 Inhibitor 98.36%
    X-376 是一种有效的高特异性 ALK 酪氨酸激酶抑制剂 (TKI) (IC50=0.61 nM)。X-376 是 MET 的较低效抑制剂 (IC50=0.69 nM)。X-376 具有有效的抗肿瘤活性。
  • HY-18030A
    CEP-28122 mesylate salt Inhibitor 99.85%
    CEP-28122甲磺酸盐是一种高度有效的选择性ALK抑制剂, IC50值为1.9 ± 0.5 nM。
  • HY-15358
    ALK inhibitor 2 Inhibitor 99.77%
    ALK inhibitor 2 (compound 18) 是一种有效的,嘧啶类 ALK 抑制剂。ALK inhibitor 2 是有效的睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2; IC50=37 nM) 和粘着斑激酶 (FAK; IC50=5 nM) 抑制剂。
  • HY-15801
    HG-14-10-04 Inhibitor 98.83%
    HG-14-10-04 (example 10) is a potent and specific ALK inhibitor with IC50 of 20 nM.
  • HY-112140
    JH-VIII-157-02 Inhibitor 98.86%
    JH-VIII-157-02 是 alectinib 的结构类似物,为 ALK 抑制剂,对棘皮动物微管相关蛋白样 4 (EML4)-ALK G1202R 的 IC50 值为 2 nM。
  • HY-N4126
    6-Demethoxytangeretin Inhibitor 99.28%
    6-​Demethoxytangeretin 6-去甲氧基三苯甲基黄嘌呤是从柑橘 (Citrus depressa) 分离的黄酮。 6-Demethoxytangeretin 具有抗炎和抗过敏活性,通过间变性淋巴瘤激酶 (ALK) 和丝裂原活化蛋白激酶 (MAPK) 途径抑制人肥大细胞中 IL-6 的产生和基因表达。6-​Demethoxytangeretin 促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。
  • HY-125851
    TGFβRI-IN-2 Inhibitor
    TGFβRI-IN-2 (compound 18) 是一种有效的,选择性的和口服活性的激活素样激酶 5 (ALK 5) 抑制剂,pIC50pEC50 值分别为 7.6 和 6.63。TGFβRI-IN-2 在高剂量时会在体内产生心脏毒性。
  • HY-136194
    TL13-22 Inhibitor
    TL13-22 是 一种 TL13-12 (HY-122582) 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.54 nM。TL13-22 不会降解细胞中的 ALK
  • HY-136195
    TL13-110 Inhibitor
    TL13-110 是 一种 TL13-112 (HY-123919) 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.34 nM。TL13-110 不会降解细胞中的 ALK
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