2. 重组蛋白
  3. CAR-T related Proteins

CAR-T related Proteins  (CAR-T 相关蛋白)

嵌合抗原受体T (CAR-T) 细胞是通过基因工程表达特异性合成抗原受体的T 细胞，能够特异性地靶向抗原并杀死肿瘤细胞。CAR-T细胞能够通过单链可变区片段 (scFv) 结合域特异性识别其靶抗原，以独立于主要组织相容性复合体 (MHC) 的方式激活。CAR 分子通常包括 3 个组分：1）参与抗原鉴定的细胞外结构域，它由一个单链可变区片段 (scFv) 组成，特异性识别肿瘤相关抗原 (TAA)。scFV 通过跨膜区固定在 T 细胞上，跨膜区由CD3、CD8、CD28或FcεRI的跨膜区域组成，与 3）胞内区连接。胞内区由CD8、CD28或CD137和CD3ζ的胞质内区域构成，包含了激活共刺激信号的免疫受体酪氨酸激活基序 (ITAM)。

Chimeric antigen receptor T (CAR-T) cells, which are genetically engineered to express specific synthetic antigen receptors, can specifically target antigens and kill tumor cells. CAR-T cells are capable of specifically recognizing their target antigen through the single-chain fragment variable (scFv) binding domain, resulting in T cell activation in a major histocompatibility complex (MHC)-independent manner. Generally, CAR molecules are composed of 3 components: 1) an extracellular domain involved in antigen identification, which is composed of a scFv that (specifically) recognizes tumor-associated antigens (TAA). scFV is fixed on T cell by a 2) transmembrane domain, composed of a transmembrane region of CD3, CD8, CD28 or FcεRI. This region is connected to the 3) intracellular zone, composed of the intracytoplasmic region of CD8, CD28 or CD137 and CD3ζ. This zone comprises the immune receptor tyrosine-based activation motif (ITAM) which activates the costimulatory signal.

 
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