1. 重组蛋白
  2. Enzymes & Regulators
  3. Protease Inhibitors

Protease Inhibitors  (蛋白酶抑制剂蛋白)

许多生物功能依赖于蛋白酶,包括食物消化、溶酶体降解和信号级联。 由于蛋白酶引发了一个不可逆的事件,即蛋白质的水解,它们的活性必须受到严格控制。 蛋白酶抑制剂的广泛调控网络已经形成,以确保其活性的靶向空间和时间控制。 自然发生的蛋白酶抑制剂 (抗蛋白酶) 通常是蛋白质或多肽,它们控制生物体内的蛋白质水解,以及竞争或掠夺性地使蛋白酶灭活。 根据蛋白酶活性部位的作用机制,蛋白酶抑制剂可进一步分为5类 (丝氨酸、苏氨酸、半胱氨酸、天冬氨酸和金属蛋白酶抑制剂)。 一些蛋白酶抑制剂干扰不止一种蛋白酶。 例如,丝氨酸家族的蛋白酶抑制剂 (serpins) 通常被认为对丝氨酸蛋白酶有活性,但也有一些serpins 被鉴定具有半胱氨酸蛋白酶和papain 样半胱氨酸蛋白酶抑制活性。

Many biological functions rely upon proteases, including food digestion, lysosomal degradation, and signaling cascades. Since proteases trigger an irreversible event, the hydrolysis of a protein, their activity must be tightly controlled. An extensive regulatory network of protease inhibitors has evolved to ensure targeted spatial and temporal control of their activity. Naturally occurring protease inhibitors (antiproteases) are usually proteins or peptides, which control proteolysis within an organism, as well as inactivate proteases of competing or predatory species. Protease inhibitors can be further classified into 5 groups (serine, threonine, cysteine, aspartyl and metalloprotease inhibitors) according to the mechanism employed at the active site of proteases they inhibit. Some protease inhibitors interfere with more than one type of protease. For example, the serine family of protease inhibitors (serpins) is generally known as active against serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified.

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