1. Signaling Pathways
  2. Immunology/Inflammation
  3. ALCAM/CD166

ALCAM/CD166 (活化的白细胞粘附分子)

Activated Leukocyte Cell Adhesion Molecule

ALCAM (CD166),一种细胞表面糖蛋白,是免疫球蛋白超家族的细胞粘附分子。ALCAM 在多种细胞类型表达,例如白细胞和内皮细胞 (EC)。ALCAM 可以结合 T 细胞表达的清道夫受体 CD6、内皮 L1CAM 和半乳糖凝集素 8。ALCAM 调节多种病理生理过程,包括 T 细胞活化、白细胞运输和血管生成。ALCAM 是一种癌症标志物,可通过控制细胞增殖、粘附、迁移和侵袭促进肿瘤生长[1][2]

ALCAM (CD166), a cell surface glycoprotein, is a cell adhesion molecule of the immunoglobulin superfamily. ALCAM is expressed by various cell types, such as leukocytes and endothelial cells (ECs). ALCAM can bind to the T cell-expressed scavenger receptor CD6, endothelial L1CAM, and galectin-8. ALCAM regulates diverse pathophysiological processes, including T cell activation, leukocyte trafficking, and angiogenesis. ALCAM is a prognostic marker of cancers. ALCAM promotes tumor growth by controlling cell proliferation, adhesion, migration and invasion[1][2].

ALCAM/CD166 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99788
    Praluzatamab Inhibitor
    Praluzatamab 是一种靶向活化白细胞粘附分子 (ALCAM/CD116) 的单克隆抗体。Praluzatamab 可用于合成 Praluzatamab ravtansine (抗体活性分子偶联物)。Praluzatamab 可用于癌症研究。