1. Signaling Pathways
  2. Immunology/Inflammation
  3. CD28


CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4. CD28 interacts with the CD80 dimer with relatively high affinity and the CD86 monomer with lower affinity, mediating T cell co-stimulation in conjunction with T cell receptor (TCR) signals. CD28 drives critical intracellular biochemical events including unique phosphorylation and transcriptional signaling, metabolism, and the production of key cytokines, chemokines, and survival signals that are essential for long-term expansion and differentiation of T cells. Most importantly, treatment of mice with a soluble CD28 antagonist induced antigen-specific tolerance that prevented the progression of autoimmune diseases and organ graft rejection.

CD28 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-102090
    B7/CD28 interaction inhibitor 1 99.68%
    B7/CD28 interaction inhibitor 1 (copmound 6b) 是一种有效的 B7.1-CD28 相互作用抑制剂,IC50 为 50 nM。
  • HY-100891
    CD80-IN-3 98.22%
    CD80-IN-3 是有效的 CD80 抑制剂,抑制 CD80/CD28 互作的 EC50 值为 630 nM,Kd 值为 125 nM。
  • HY-P1698
    Reltecimod Antagonist
    Reltecimod (AB-103) 是一种 T 细胞特异性表面糖蛋白 CD28 (TP44) 拮抗剂。Reltecimod对不同的细菌感染、细菌外毒素和内毒素以及电离辐射都有良好的抗性作用。Reltecimod 通过靶向和减弱关键的 CD28/B7-2 共刺激通路来调节炎症反应,而不抑制它。Reltecimod 可用于研究坏死性软组织感染 (NSTIs)。