1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. GPR119

GPR119

GPR119 (G protein-coupled receptor 119) is a G protein-coupled receptor that in humans is encoded by the GPR119 gene. GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments forobesity and diabetes.

GPR119 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-15565
    APD668 Agonist 99.71%
    APD668 是一种有效的,选择性和具有口服活性的 G 蛋白偶联受体 GPR119 激动剂,对 hGPR119rGPR119EC50 值分别为 2.7 nM 和 33 nM。APD668 对除 CYP2C9 (Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。APD668 可用于脂肪性肝炎和糖尿病的研究。
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