1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Kinesin

Kinesin (驱动蛋白)

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

  • Kinesin-5/Eg5/KSP

  • Kinesin-6

  • Kinesin-7/CENP-E

  • Kinesin-12

  • Kinesin-14

Kinesin 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-101071A
    Monastrol Inhibitor 99.95%
    Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白 Eg5 的抑制剂,IC50 值为 14 μM。
  • HY-12241
    AZ82 Inhibitor ≥98.0%
    AZ82 是一种驱动蛋白样蛋白 KIFC1 (HSET/KIFC1) 的选择性抑制剂,其 Ki 值和 IC50 值分别为 43 nM 和 300 nM。
  • HY-15948
    Kif15-IN-1 Inhibitor 99.53%
    Kif15-IN-1 是一种驱动蛋白家族 15 (Kif15) 的抑制剂,主要用于细胞增殖性疾病的研究。
  • HY-101298
    Paprotrain Inhibitor 99.54%
    Paprotrain是可渗透细胞的kinesin MKLP-2 的抑制剂,抑制 MKLP-2 的 ATPase 活性,IC50 值为 1.35 μM,Ki 值为 3.36 μM,同时对 DYRK1A 有中等的抑制作用,IC50值为 5.5 μM。
  • HY-12069
    SB-743921 Inhibitor 98.11%
    SB-743921 是一种有效的驱动蛋白 (Eg5) 抑制剂,Ki 值为 0.1 nM。
  • HY-115570
    GW406108X Inhibitor ≥98.0%
    GW406108X 是特异性的 Kif15 (Kinesin-12) 抑制剂,IC50 为 0.82 uM。GW406108X 是一种有效的自噬 (autophagy) 抑制剂, ATP 竞争性抑制 ULK1pIC50 为 6.37 (427 nM)。GW406108X 抑制 ULK1 和自噬,而不影响 mTOR 或 AMPK 活性。
  • HY-112915
    Eg5 Inhibitor V, trans-24 Inhibitor
    Eg5 Inhibitor V, trans-24 是一种有效的、特异性的驱动蛋白 Eg5 抑制剂,IC50 值为 0.65 μM,可用于癌症的研究。
  • HY-14846
    Litronesib Inhibitor 99.59%
    Litronesib (LY2523355) 是一种选择性的有丝分裂特异性运动蛋白 Eg5 抑制剂,具有抗肿瘤的活性。
  • HY-19530
    PF-2771 Inhibitor 99.56%
    PF-2771 是一种选择性的着丝粒蛋白 E (CENP-E) 抑制剂,IC50 值为 16.1 nM,具有抗肿瘤活性。
  • HY-15857
    CW-069 Inhibitor 99.75%
    CW-069 是一种微管运动蛋白 HSET 的别构抑制剂,IC50 值为 75 μM。
  • HY-19944
    Dimethylenastron Inhibitor 98.24%
    Dimethylenastron 是一种有效的驱动蛋白 Eg5 抑制剂,IC50 值为 200 nM。
  • HY-14846A
    Litronesib Racemate 99.20%
    Litronesib Racemate (LY2523355 Racemate) 是 litronesib 的外消旋体。Litronesib 是选择性的驱动蛋白 Eg5 别构抑制剂。
  • HY-15949
    Kif15-IN-2 Inhibitor 98.64%
    Kif15-IN-2 是一种驱动蛋白 Kif15 的抑制剂,主要用于细胞增殖性疾病的研究。
Isoform Specific Products

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