1. 重组蛋白
  2. Receptor Proteins
  3. Nuclear Receptor Superfamily

Nuclear Receptor Superfamily  (核受体超家族)

Nuclear receptors (NRs) are important transcription factors capable of exerting regulation of gene expression in the nucleus in response to various extracellular and intracellular signals. NRs are activated by binding of small hydrophobic compounds, such as steroids, retinoids, and thyroid hormones. The interaction of ligand and receptor triggers a conformational change in the receptor proteins, which enables an interaction with cofactors and specific cis-regulatory DNA sequences called hormone response elements (HREs) to subsequently modify gene expression. NRs are involved in widely diverse physiological functions such as control of development, reproduction, metabolism, cell differentiation, and homeostasis. NRs share a similar modular domain structure, which includes, from N-terminus to C-terminus: 1) domains A and B make up the highly variable (both in length and sequence) amino/N-terminal domain (NTD); 2) the DNA-binding domain (DBD), which consists of two zinc finger DNA-binding motifs; 3) the hinge D-region, often contains the main nuclear localization sequence (NLS); 4) the ligand-binding domain (LBD); 5) some receptors also contain a short, variable carboxy/C-terminal domain (CTD; F domain). Most NRs are regulated endogenously by small lipophilic ligands, but this protein family also contains “orphan” members for which lack identified ligand molecules. NRs are divided into seven subfamilies, Subgroup 0 to Subgroup 6, based on sequence alignment and phylogenetic tree construction. Among them, the Subgroup 1 is large family which is formed by thyroid hormone receptors (TR), retinoic acid receptors (RAR), peroxisome proliferator activated receptors (PPAR), reverse-Erb receptors (REV-ERB, retinoic acid related receptors (ROR), farnesoid X receptors (FXR), liver X receptors (LXR), and vitamin D receptors (VDR).

目录号 产品名 / 同用名 种属 表达系统
  • HY-P7996
    PPAR alpha Protein, Human (His)

    PPARA, PPAR-α

    Human E. coli
    PPAR alpha Protein, human (His) 是核受体家族的成员,是一种转录因子,以配体依赖性方式调节与脂质代谢相关的基因表达。
  • HY-P70248
    ER alpha/ESR1 Protein, Human (His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    Human E. coli
    ERα/ESR1蛋白是一种核受体,在基因表达中发挥关键的调节作用,影响细胞增殖和分化。配体依赖性反式激活涉及同型二聚体与雌激素反应元件的结合或与转录因子的关联。ER alpha/ESR1 Protein, Human (His) 是重组的 ER α/ESR1 蛋白,由 E. coli 表达,带有 N-6*His 标签。ER alpha/ESR1 Protein, Human (His) 全长 116 个氨基酸,分子量约为 ~14 kDa。
  • HY-P70791
    ER beta/ESR2 Protein, Human (His)

    Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2

    Human E. coli
    ER beta/ESR2 蛋白是一种核激素受体,与 ESR1/ER-alpha 类似,可结合雌激素。它通过 ERE 激活雌激素依赖性报告基因。然而,它缺乏配体结合能力并且表现出最小的ERE结合,导致配体依赖性反式激活能力的丧失。ER beta/ESR2 Protein, Human (His) 是重组的 ER beta/ESR2 蛋白,由 E. coli 表达,带有 N-6*His 标签。ER beta/ESR2 Protein, Human (His) 全长 323 个氨基酸,分子量为 35-40 kDa。
  • HY-P72088
    Androgen receptor Protein, Human (His-SUMO)

    AIS; ANDR_HUMAN; Androgen nuclear receptor variant 2; Androgen receptor dihydrotestosterone receptor; testicular feminization; SBMA; SMAX1; Testicular Feminization TFM; TFM

    Human E. coli
    雄激素受体蛋白是一种类固醇激素受体,作为配体激活的转录因子,调节基因表达并影响细胞增殖和分化。ZBTB7A 等共激活剂和辅阻抑剂通过将 NCOR1 和 NCOR2 招募到靶基因上的雄激素反应元件来负向调节雄激素受体信号。Androgen receptor Protein, Human (His-SUMO) 是重组的 雄激素受体蛋白,由 E. coli 表达,带有 N-10*His, N-SUMO, C-Myc 标签。Androgen receptor Protein, Human (His-SUMO) 全长 369 个氨基酸,分子量约为 ~62.4 kDa。
  • HY-P7999
    PPAR gamma Protein, Human (His)

    PPAR-γ-LBD

    Human E. coli
    PPAR gamma LBD Protein, Human (His)是融合了 His 标签的人源的 PPAR-gamma 蛋白,E. coli 表达系统,约 32.6 kDa。PPAR gamma LBD Protein, Human (His) 可用于配体筛选试验、western blotting 和 ELISA 等。
  • HY-P700275
    PPAR gamma Protein, Human (C-His)

    PPAR-γ-LBD

    Human E. coli
    PPAR γ 蛋白是一种核受体,与过氧化物酶体增殖物结合,在配体与 DNA 上的特定 PPRE 结合后激活。它调节靶基因转录,控制脂肪酸代谢。PPAR gamma 在脂肪细胞分化和葡萄糖稳态中至关重要,可抑制 NF-kappa-B 介导的炎症,调节心血管昼夜节律中的 BMAL1,并通过影响 MAPK p38 磷酸化和 IL-6 产生来调节对结核分枝杆菌的免疫反应。PPAR gamma Protein, Human (C-His) 是重组的 PPAR γ 蛋白,由 E. coli 表达,带有 C-6*His 标签。PPAR gamma Protein, Human (C-His) 全长 266 个氨基酸,分子量约为 ~30 kDa。
  • HY-P701404
    LXR-α Protein, Human

    NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

    Human E. coli
    LXR-α 蛋白是一种核受体,通过与 RXR 相互作用来激活转录。它通过 MYLIP 依赖性泛素化调节胆固醇摄取,对于胆固醇稳态至关重要。LXR-α Protein, Human 是重组的 LXR-α 蛋白,由 E. coli 表达,不带标签。LXR-α Protein, Human 全长 266 个氨基酸。
  • HY-P73701
    PPAR gamma Protein, Human (sf9, His-GST)

    CIMT1; GLM1; NR1C31; PPARG2; PPARG5; PPARgamma; PPARG

    Human Sf9 insect cells
    PPAR γ 蛋白是一种与过氧化物酶体增殖物结合的核受体,并在配体与 DNA 上的特定 PPRE 结合时被激活。它调节靶基因转录并控制脂肪酸代谢。PPAR gamma Protein, Human (sf9, His-GST) 是重组的 PPAR γ 蛋白,由 Sf9 insect cells 表达,带有 N-His, N-GST 标签。PPAR gamma Protein, Human (sf9, His-GST) 全长 505 个氨基酸,分子量约为 ~85.4 kDa。
  • HY-P701336
    PPAR gamma Protein, Human

    PPARG; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3

    Human E. coli
    PPAR γ 蛋白是一种与过氧化物酶体增殖物结合的核受体,并在配体与 DNA 上的特定 PPRE 结合时被激活。它调节靶基因转录并控制脂肪酸代谢。PPAR gamma Protein, Human 是重组的 PPAR γ 蛋白,由 E. coli 表达,不带标签。PPAR gamma Protein, Human 全长 272 个氨基酸。
  • HY-P701405
    LXR-α Protein, Human (His)

    NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

    Human E. coli
    LXR-α 蛋白是一种核受体,通过与 RXR 相互作用来激活转录。它通过 MYLIP 依赖性泛素化调节胆固醇摄取,对于胆固醇稳态至关重要。LXR-α Protein, Human (His) 是重组的 LXR-α 蛋白,由 E. coli 表达,带有 N-6*His 标签。LXR-α Protein, Human (His) 全长 266 个氨基酸。
  • HY-P701402
    RXRB Protein, Human

    RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

    Human E. coli
    RXRB蛋白是视黄酸的受体,形成异二聚体,尤其是RAR/RXR,通过视黄酸反应元件(RARE)调节基因表达。RXRB 表现出同二聚化并与其他视黄酸受体家族成员形成异二聚体。RXRB Protein, Human 是重组的 RXRB 蛋白,由 E. coli 表达,不带标签。RXRB Protein, Human 全长 235 个氨基酸。
  • HY-P701403
    RXRB Protein, Human (His)

    RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

    Human E. coli
    RXRB蛋白是视黄酸的受体,形成异二聚体,尤其是RAR/RXR,通过视黄酸反应元件(RARE)调节基因表达。RXRB 表现出同二聚化并与其他视黄酸受体家族成员形成异二聚体。RXRB Protein, Human (His) 是重组的 RXRB 蛋白,由 E. coli 表达,带有 N-6*His 标签。RXRB Protein, Human (His) 全长 235 个氨基酸。
  • HY-P702572
    PPAR gamma Protein, Human (P.pastoris, His)

    CIMT1, GLM1, NR1C31, PPARG2, PPARG5, PPARgamma, PPARG

    Human P. pastoris
    PPAR γ 蛋白是一种与过氧化物酶体增殖物结合的核受体,并在配体与 DNA 上的特定 PPRE 结合时被激活。它调节靶基因转录并控制脂肪酸代谢。PPAR gamma Protein, Human (P.pastoris, His) 是重组的 PPAR γ 蛋白,由 P. pastoris 表达,带有 N-6*His 标签。PPAR gamma Protein, Human (P.pastoris, His) 全长 477 个氨基酸,分子量为 56.3 kDa。
目录号 产品名 作用方式 纯度