1. Signaling Pathways
  2. Immunology/Inflammation
    Metabolic Enzyme/Protease
  3. Arginase

Arginase (精氨酸酶)

Arginase (ARG) is an enzyme involved in urea cycle, where it catalyzes the hydrolysis of L-arginine into L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular localization, and molecular regulation. Arginase activity has two major homeostatic purposes: first, to rid the body of ammonia through urea synthesis, and second, to produce ornithine, the precursor for polyamines and prolines. Polyamines produced through ornithine decarboxylase (ODC) are necessary for cell proliferation and regulation of several ion channels. Proline produced through ornithine aminotransferase (OAT) is necessary for production of collagen.

Arginase I is a cytosolic enzyme that is abundantly expressed in the liver and plays an essential role in hepatic urea cycle. In contrast, arginase II is a mitochondrial enzyme that is widely expressed outside the liver, most prominently in the kidney and prostate. Arginase functions important for protection against NH3 toxicity and cell growth and repair. Excessive arginase activity in mammals has been associated with cardiovascular and nervous system dysfunction and disease. Two relevant aspects of this elevated activity may be involved in these disease states. First, excessive arginase activity reduces the supply of L-arginine needed by nitric oxide (NO) synthase to produce NO. Second, excessive production of ornithine leads to vascular structural problems and neural toxicity. In addition, Arginase is a potential therapeutic target for the treatment of sexual arousal disorders in men and women.

Arginase 相关产品 (10):

目录号 产品名 作用方式 纯度
  • HY-101979A
    Numidargistat dihydrochloride Inhibitor ≥98.0%
    Numidargistat (CB-1158) dihydrochloride 是一种有效的,具有口服活性的精氨酸酶 (arginase) 抑制剂,对重组人 arginase 1arginase 2IC50 值分别为 86 nM 和 296 nM。免疫肿瘤剂。
  • HY-19548A
    BEC hydrochloride Inhibitor ≥98.0%
    BEC hydrochloride 是一种缓慢结合的竞争性精氨酸酶 II ( Arginase II) 抑制剂,在 pH 7.5 和 pH 9.5 时 Ki 值分别为 0.31 μM 和 30 nM。
  • HY-15775
    Arginase inhibitor 1 Inhibitor ≥98.0%
    Arginase inhibitor 1 是一种有效的人精氨酸酶 (arginases III)抑制剂,IC50 分别为 223 和 509 nM。
  • HY-112885B
    nor-NOHA monoacetate Inhibitor 99.96%
    nor-NOHA (Nω-Hydroxy-nor-L-arginine) monoacetate 是一种有效的选择性精氨酸酶抑制剂。nor-NOHA monoacetate 抑制大鼠肝精氨酸酶,Ki 值为 0.5 µM。
  • HY-112885A
    nor-NOHA acetate Inhibitor ≥99.0%
    nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种特异性、可逆的 arginase 抑制剂,在缺氧条件下,可诱导 ARG2 表达细胞的凋亡。具有抗白血病的作用,同时在内皮功能障碍、免疫抑制及代谢中有效。
  • HY-N2237
    Piceatannol 3'-O-glucoside Inhibitor ≥99.0%
    Piceatannol 3'-O-glucoside 是 Rhubarb 的一种活性成分,通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase),抑制 Arginase IArginase IIIC50 值分别为 11.22 μM 和 11.06 μM。
  • HY-101979
    Numidargistat Inhibitor
    Numidargistat (CB-1158) 是一种有效的,具有口服活性的精氨酸酶 (arginase) 抑制剂,对重组人 arginase 1arginase 2IC50 值分别为 86 nM 和 296 nM。免疫肿瘤剂。
  • HY-W062216
    2-Aminoimidazole Inhibitor
    2-Aminoimidazole 是一种有效的抗生物膜剂,可用作抗菌佐剂。2-Aminoimidazole 通过抑制生物被膜的形成和基因编码的抗生素抗性特征来破坏细菌自我保护的能力。2-Aminoimidazole 也是一种弱的非竞争性人精氨酸酶 I (human arginase I) 抑制剂,Ki 值为 3.6 mM。
  • HY-W010510
    DL-Norvaline Inhibitor
    DL-Norvaline 是 L-norvaline 的代谢物,L-norvaline 是精氨酸酶 (arginase) 的非竞争性抑制剂。
  • HY-126332
    NED-3238 Inhibitor
    NED-3238 是一种高效的精氨酸酶 I 和 II 抑制剂,IC50 值分别为 1.3 nM 和 8.1 nM。
Isoform Specific Products

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