1. Signaling Pathways
  2. Immunology/Inflammation
    Metabolic Enzyme/Protease
  3. Arginase


Arginase, an enzyme within the urea cycle in the liver, is also found in many other cells and tissues, including the lung. Arginase is present in 2 isoforms: arginase I, the hepatic isoform; and arginase II, the extrahepatic isoform; each of which is encoded by a distinct gene.

The expression and function of arginase I in macrophages, hepatocytes, and vascular smooth muscle cells, is stimulated by lipopolysaccharide (LPS), IL-13, altered oxygen tension, and balloon dilatation of coronary arteries. The activation and expression of endothelial arginase II can also be induced by a variety of vascular insults.

Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Inhibition of arginase activity enhances a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis. Arginase inhibition actively augments NO production and has beneficial effects on normal cardiac function and on vascular dysfunction typical of atherogenesis, aging, and erectile dysfunction, and sickle cell disease.

Arginase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-101979A
    CB-1158 dihydrochloride Inhibitor >98.0%
    CB-1158 dihydrochloride (INCB01158 dihydrochloride) 是一种有效的,可口服的精氨酸酶 (arginase) 抑制剂,对重组人 arginase 1/2 的 IC50 值分别为 86 和 296 nM。
  • HY-15775
    Arginase inhibitor 1 Inhibitor 98.00%
    Arginase inhibitor 1 是一种有效的人精氨酸酶 (arginases III)抑制剂,IC50 分别为 223 和 509 nM。
  • HY-19548A
    BEC hydrochloride Inhibitor >98.0%
    BEC hydrochloride 是一个竞争性的 Arginase II抑制剂,Ki值是0.31 uM (ph 7.5)。
  • HY-112885A
    nor-NOHA acetate Inhibitor >99.0%
    nor-NOHA acetate 是一种特异性、可逆的 arginase 抑制剂,在缺氧条件下,可诱导 ARG2 表达细胞的凋亡。具有抗白血病的作用,同时在内皮功能障碍、免疫抑制及代谢中有效。
  • HY-W010510
    DL-Norvaline Inhibitor
    DL-Norvaline 是 L-norvaline 的代谢物,L-norvaline 是精氨酸酶 (arginase) 的非竞争性抑制剂。
  • HY-126332
    NED-3238 Inhibitor
    NED-3238 是一种高效的精氨酸酶 I 和 II 抑制剂,IC50 值分别为 1.3 nM 和 8.1 nM。
  • HY-N2237
    Piceatannol 3'-O-glucoside Inhibitor >99.0%
    Piceatannol 3'-O-glucoside 是 Rhubarb 的一种活性成分,通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase),抑制 Arginase IArginase IIIC50 值分别为 11.22 μM 和 11.06 μM。
  • HY-101979
    CB-1158 Inhibitor
    CB-1158 是一种有效的,可口服的精氨酸酶 (arginase) 抑制剂,对重组人 arginase 1/2 的 IC50 值分别为 86 和 296 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.