1. Signaling Pathways
  2. Immunology/Inflammation
    Metabolic Enzyme/Protease
  3. Arginase

Arginase (精氨酸酶)

Arginase, an enzyme within the urea cycle in the liver, is also found in many other cells and tissues, including the lung. Arginase is present in 2 isoforms: arginase I, the hepatic isoform; and arginase II, the extrahepatic isoform; each of which is encoded by a distinct gene.

The expression and function of arginase I in macrophages, hepatocytes, and vascular smooth muscle cells, is stimulated by lipopolysaccharide (LPS), IL-13, altered oxygen tension, and balloon dilatation of coronary arteries. The activation and expression of endothelial arginase II can also be induced by a variety of vascular insults.

Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Inhibition of arginase activity enhances a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis. Arginase inhibition actively augments NO production and has beneficial effects on normal cardiac function and on vascular dysfunction typical of atherogenesis, aging, and erectile dysfunction, and sickle cell disease.

Arginase 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-19548A
    BEC hydrochloride Inhibitor ≥98.0%
    BEC hydrochloride 是一种缓慢结合的竞争性精氨酸酶 II ( Arginase II) 抑制剂,在 pH 7.5 和 pH 9.5 时 Ki 值分别为 0.31 μM 和 30 nM。
  • HY-15775
    Arginase inhibitor 1 Inhibitor ≥98.0%
    Arginase inhibitor 1 是一种有效的人精氨酸酶 (arginases III)抑制剂,IC50 分别为 223 和 509 nM。
  • HY-112885A
    nor-NOHA acetate Inhibitor ≥99.0%
    nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种特异性、可逆的 arginase 抑制剂,在缺氧条件下,可诱导 ARG2 表达细胞的凋亡。具有抗白血病的作用,同时在内皮功能障碍、免疫抑制及代谢中有效。
  • HY-112885B
    nor-NOHA monoacetate Inhibitor 99.33%
    nor-NOHA (Nω-Hydroxy-nor-L-arginine) monoacetate 是一种有效的选择性精氨酸酶抑制剂。nor-NOHA monoacetate 抑制大鼠肝精氨酸酶,Ki 值为 0.5 µM。
  • HY-N2237
    Piceatannol 3'-O-glucoside Inhibitor ≥99.0%
    Piceatannol 3'-O-glucoside 是 Rhubarb 的一种活性成分,通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase),抑制 Arginase IArginase IIIC50 值分别为 11.22 μM 和 11.06 μM。
  • HY-W062216
    2-Aminoimidazole Inhibitor
    2-Aminoimidazole 是一种有效的抗生物膜剂,可用作抗菌佐剂。2-Aminoimidazole 通过抑制生物被膜的形成和基因编码的抗生素抗性特征来破坏细菌自我保护的能力。2-Aminoimidazole 也是一种弱的非竞争性人精氨酸酶 I (human arginase I) 抑制剂,Ki 值为 3.6 mM。
  • HY-W010510
    DL-Norvaline Inhibitor
    DL-Norvaline 是 L-norvaline 的代谢物,L-norvaline 是精氨酸酶 (arginase) 的非竞争性抑制剂。
Isoform Specific Products

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