2. 重组蛋白
  3. Ubiquitin Related Proteins

Ubiquitin Related Proteins  (泛素相关蛋白)

泛素 (Ub) 是真核细胞中广泛表达的一种高度保守的小分子蛋白，由 76 个氨基酸组成。泛素共价结合到靶蛋白上被称为“泛素化”，泛素化是一种重要的蛋白质翻译后修饰 (PTM)。泛素化在控制蛋白的稳定和功能中起重要作用，并调节了多种细胞过程，例如细胞分裂和分化、环境应激反应、细胞分化、免疫反应、DNA修复和凋亡。著名的泛素-蛋白酶体途径 (UPP) 是主要的胞质蛋白水解机制，能选择性降解各种形式的受损蛋白。 泛素化修饰由三类酶催化完成：1） 泛素激活酶 E1 激活泛素蛋白；2）激活的泛素转移到泛素结合酶E2 的 Cys残基上；3）泛素由E3连接酶连接到靶蛋白的赖氨酸残基上。

Ubiquitin (Ub) is a highly conserved small protein containing 76 amino acids that is ubiquitously expressed in eukaryotic cells. The covalent attachment of ubiquitin to target proteins, namely ubiquitination, is an important type of protein posttranslational modification (PTM). Ubiquitination plays a crucial role in controlling various proteins’ stability and functions, regulating many cellular pathways, such as cell division and differentiation, response to environmental stress, cell differentiation, immune response, DNA repair, and apoptosis. The ubiquitin-proteasome pathway (UPP), a well-known pathway, is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins. Ubiquitination occurs in a three-step reaction requiring three different enzymes: 1) Ubiquitin activation by an Ub -activating enzyme (E1); 2) Activated ubiquitin is transferred from E1 to a cysteinyl residue in an Ub-conjugating enzyme (E2); 3) Ubiquitin is ligated to the lysine residues of target proteins by an Ub-ligase enzyme (E3).

 
目录号 产品名 / 同用名 种属 表达系统
  • HY-P73466
    UCHL1 Protein, Mouse (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; Uchl1; PGP9.5

    		Mouse E. coli
  • HY-P76007
    RNF43 Protein, Human (HEK293, Fc)

    E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RNF43

    		Human HEK293
  • HY-P74479
    USP5 Protein, Human (sf9, His)

    Ubiquitin carboxyl-terminal hydrolase 5; Isopeptidase T; USP5; ISOT

    		Human Sf9 insect cells
  • HY-P71096
    UCHL1 Protein, Human (His)

    Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; UCH-L1; Neuron Cytoplasmic Protein 9.5; PGP 9.5; PGP9.5; Ubiquitin Thioesterase L1; UCHL1

    		Human E. coli
  • HY-P71398
    UBE2B Protein, Human (HEK293, His)

    Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B

    		Human HEK293
  • HY-P71418
    USP14 Protein, Human (His)

    Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiquitin Thioesterase 14; Ubiquitin-Specific-Processing Protease 14; USP14; TGT

    		Human E. coli
  • HY-P73485
    XIAP Protein, Human (Avi)

    E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4

    		Human E. coli
  • HY-P73537
    XIAP Protein, Human (His)

    E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4

    		Human E. coli
  • HY-P74483
    UCHL1 Protein, Rat (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; Uchl1; PGP9.5

    		Rat E. coli
  • HY-P74485
    UBA1 Protein, Human (sf9, His-GST)

    Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1

    		Human Sf9 insect cells
  • HY-P75897
    KEAP1 Protein, Human (sf9)

    Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1

    		Human Sf9 insect cells
  • HY-P75898
    KEAP1 Protein, Human (sf9, His-GST-Avi)

    Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1

    		Human Sf9 insect cells
  • HY-P75968
    PDHA1 Protein, Human (sf9, His-GST)

    Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; PHE1A

    		Human Sf9 insect cells
  • HY-P76119
    UCHL3 Protein, Mouse (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3

    		Mouse E. coli
  • HY-P7617
    ATG3 Protein, Human

    rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L

    		Human E. coli
    ATG3 Protein, Human是一种在 E. coli 中表达的重组人 Ubiquitin-like-conjugating Enzyme ATG3。ATG3 是用于 LC3 脂化过程的 E2 泛素结合酶，对于自噬至关重要。
  • HY-P77277
    USP46 Protein, Human/Mouse (sf9)

    Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Usp46

    		Human; Mouse Sf9 insect cells
  • HY-P70149
    ISG15/UCRP Protein, Human (His)

    rHuISG15/UCRP, His; Ubiquitin-Like Protein ISG15; Interferon-Induced 15 kDa Protein; Interferon-Induced 17 kDa Protein; IP17; Ubiquitin Cross-Reactive Protein; hUCRP; ISG15; G1P2; UCRP

    		Human E. coli
  • HY-P71399
    UBE2D1 Protein, Human (GST)

    Ubiquitin-conjugating enzyme E2 D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1; SFT; UBC5A; UBCH5; UBCH5A

    		Human E. coli
  • HY-P71395
    UBA5 Protein, Human (His)

    Ubiquitin-like modifier-activating enzyme 5; ThiFP1; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1; UBE1DC1; UBA5

    		Human E. coli
  • HY-P70998
    UBE2D3 Protein, Human

    Ubiquitin-conjugating enzyme E2 D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.

    		Human E. coli
目录号 产品名 作用方式 纯度