1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. G-quadruplex

G-quadruplex

G-quadruplexes (G-tetrads or G4-DNA) are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure. Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad, and two or more guanine tetrads can stack on top of each other to form a G-quadruplex. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular or tetramolecular. Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel.

G-quadruplex 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-15176A
    Pyridostatin hydrochloride Activator >98.0%
    Pyridostatin hydrochloride (RR82 hydrochloride) 是一种 G-quadruplexe 稳定剂,Kd 值为 490 nM。
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate Inhibitor 99.53%
    Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体,可以抑制解旋酶 FANCJDinGIC50s 值分别为 65±6 和 50±10 nM。
  • HY-108477
    TMPyP4 tosylate Inhibitor >98.0%
    TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体,可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂,在骨肉瘤细胞系中具有抗肿瘤作用。
  • HY-15595A
    360A iodide Activator >98.0%
    360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-133234
    BMVC-8C3O Modulator 99.01%
    BMVC-8C3O 是一种 G4 配体,可诱导人端粒 DNA G4s 的非平行型向平行型拓扑转化。
  • HY-135775
    BMVC
    BMVC 是一种有效的 G-四联体 (G4) 稳定剂和选择性的端粒酶 (telomerase) 抑制剂,IC50 约为 0.2 μM。BMVC 抑制 Taq DNA 聚合酶,IC50 约为 2.5 μ M。BMVC 提高了端粒 G4 结构的熔化温度,并加速了端粒长度的缩短。抗癌活性。
  • HY-135776
    BMVC2
    BMVC2 (o-BMVC) 是 BMVC 的双取代咔唑衍生物,是一种 G 四联体 (G4) 稳定剂。
  • HY-15595
    360A Activator
    360A 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-15176
    Pyridostatin Activator
    Pyridostatin 是一种 G-quadruplexe 稳定剂,Kd 值为 490 nM。
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