2. 重组蛋白
  3. Cytokines and Growth Factors
  4. IGF family

IGF family  (IGF 家族)

胰岛素样生长因子 (IGF) 家族包括两个配体 (IGF-I 和IGF-II)，至少两个受体 (IGF-IR 和 IGF-IIR)，6 个高亲和力结合蛋白 (IGFBP 1-7) 和一组低亲和力IGFBP相关蛋白 (IGFBP-rPs)。IGF家族成员在自身之间以及与其他生长因子家族及其信号通路之间形成一个相互作用的网络。IGFs 在调节细胞增殖、分化、凋亡和转化中发挥重要作用。

The Insulin-Like Growth Factor (IGF) family consists of two ligands, (IGF-I and IGF-II), two cell-surface receptors (IGF-IR and IGF-IIR), at least six high affinity binding proteins (IGFBPs 1-6), and a group of low-affinity IGFBP-related proteins (IGFBP-rPs). Members of IGF family form a network of interactions both among themselves and with other growth factors families and their signalling pathways. IGFs play an important role in regulating cell proliferation, differentiation, apoptosis, and transformation.

 
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