1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Ferroportin

Ferroportin (膜铁转运蛋白)

Iron-regulated Transporter 1

Ferroportin is a membrane protein belonging to the major facilitator superfamily of transporters. Ferroportin emerges as a critical transporter in terms of iron acquisition and transfer of iron between cell types, as it is the only known transporter that exports elemental iron from cells. Ferroportin is essential to distribute iron between tissues and for iron absorption into the organism. It is inferred that the substrate for ferroportin is Fe(II), based on the observation that iron transport requires an extracellular ferroxidase activity. This ferroxidase is provided by the multicopper oxidases ceruloplasmin (Cp) and/or hephaestin. Several ferroportin mutations lead to the so-called ferroportin disease or type 4 hemochromatosis, characterized by two distinct iron accumulation phenotypes depending on whether the mutation affects the activity of the protein or its degradation pathway.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112220
    VIT-2763 99.49%
    VIT-2763 是具有口服活性的铁转运蛋白 (ferroportin) 的抑制剂,抑制hepcidin 与铁转运蛋白结合,阻滞铁外流。VIT-2763有用于地中海贫血症的潜力。
  • HY-P3267A
    Apo-Transferrin Activator
    Apo-Transferrin 是无铁的 Transferrin (HY-P3267),可作为转铁蛋白受体的配体 (Transferrin receptor) 介导内皮细胞释放铁。Apo-Transferrin 代表缺铁环境,可直接与铁黄蛋白 (hephaestin) 结合,将 Fe2+ 转化为 Fe3+。Apo-Transferrin 很可能与铁转运蛋白 1 协同介导铁流出。
  • HY-145965
    Ferroportin-IN-1 是一种铁转运蛋白 ferroportin 的抑制剂,可用于研究由缺乏铁调素或铁代谢紊乱引起的疾病,详细信息请参考专利文献 WO2020123850A1 中的化合物 23。
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