1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. c-Fms

c-Fms (集落刺激因子-1受体)

c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. c-FMS is the cell surface receptor for IL-34 and CSF1. c-FMS has important roles in haematopoiesis, regulation of proliferation, cell survival and maturation of microglia and monocytes, as well as in controlling the overall immune response.

c-FMS is specifically expressed in osteoclasts and myelomonocytic-lineage cells, such as monocytes and macrophages, and the activation of c-FMS signaling promotes the proliferation or differentiation of these cells. It also promotes the production of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL6).

c-Fms 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-10917
    GW2580 Inhibitor 99.83%
    GW2580 是口服有效的,选择性的 c-Fms 激酶抑制剂,体外实验中在 0.06 μM 时可完全抑制人 cFMS 激酶。GW2580 是 ATP 与 cFMS 激酶结合的竞争性抑制剂,并且可以抑制集落刺激因子 1 信号传导。
  • HY-10408
    Ki20227 Inhibitor 99.17%
    Ki20227 是一种口服有效,高选择性 CSF1R (c-Fms 酪氨酸激酶)抑制剂,对 CSF1R,VEGFR2 (血管内皮生长因子受体 2),c-Kit (干细胞因子受体) 和 PDGFRβ (血小板衍生的生长因子受体 β) 的 IC50 分别为 2 nM,12 nM,451 nM 和 217 nM。Ki20227 可以抑制破骨细胞分化和溶骨性破坏。
  • HY-117244
    AZD7507 Inhibitor 99.45%
    AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂,具有抗肿瘤活性。
  • HY-13838
    PLX647 Inhibitor 99.07%
    PLX647 是一种高度特异性的,具有口服活性的 FMSKIT 双激酶抑制剂,IC50 分别为 28 和 16 nM。PLX647 (1 μM) 在 400 个激酶组中显示出对 FMS 和 KIT 有选择性,但 FLT3 和 KDR 除外 (IC50=91 和 130 nM)。
  • HY-101774
    CSF1R-IN-1 Inhibitor 98.75%
    CSF1R-IN-1是 CSF1R 的抑制剂,IC50 为0.5 nM。
  • HY-112451
    cFMS Receptor Inhibitor II Inhibitor 99.68%
    cFMS Receptor Inhibitor II 是一种 CSF1R 激酶抑制剂。CSF-1 是一种细胞因子。
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