Inhibitory Checkpoint Molecules (抑制性免疫检查点)

抑制性免疫检查点分子在维持免疫稳态中起着至关重要的作用：它们效应 T 细胞上的表达确保了效应 T 细胞反应的适当紧缩；它们在调节性T (Treg) 细胞上的表达促进了Treg细胞的抑制功能。阻断共抑制分子已被证实可以增强宿主对各种癌症的免疫应答，在癌症治疗中表现出显著的临床效果。

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

Inhibitory Checkpoint Molecules 重组蛋白 (344)

种属:	Human (164) Rhesus Macaque (22) Mouse (69) Rat (26) Canine (6) Cynomolgus (36) Rabbit (2) Others (2)
标签:	His (176) Fc (118) Avi (27) GST (3) Flag (1) Myc (1) Tag Free (8)
表达系统:	E. coli (6) HEK293 (328) CHO (3) P. pastoris (2) Sf9 insect cells (5)

目录号	产品名 / 同用名	种属	表达系统

HY-P73716

PD-L1 Protein, Mouse (HEK293, His-Fc)

Programmed cell death 1 ligand 1; PD-L1; B7-H1; CD274; PDL1

Mouse

HEK293

HY-P72359

CD47 Protein, Human (Biotinylated, HEK293, Avi-His)

Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; IAP; MER6

Human

HEK293

HY-P70632

PD-L1 Protein, Mouse (HEK293, His)

Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274

Mouse

HEK293

HY-P7395

PD-1 Protein, Human (CHO, Fc) 重组人PD-1, Fc Chimera (CHO 表达) rHuPD-1, Fc Chimera; PD1; CD279; PDCD1	Human	CHO
PD-1 Protein, Human (CHO, Fc)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。

PD-1 Protein, Human (CHO, Fc)

重组人PD-1, Fc Chimera (CHO 表达)

rHuPD-1, Fc Chimera; PD1; CD279; PDCD1

Human

CHO

PD-1 Protein, Human (CHO, Fc)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。

HY-P70633

PD-L1 Protein, Mouse (220a.a, HEK293, Fc)

Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274;

Mouse

HEK293

HY-P7396

PD-1 Protein, Human (143a.a, HEK293, His) 重组人 PD-1, His (HEK293 表达) rHuPD-1, His; PD1; CD279; PDCD1	Human	HEK293
PD-1 Protein, Human (143a.a, HEK293, His)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。

PD-1 Protein, Human (143a.a, HEK293, His)

重组人 PD-1, His (HEK293 表达)

rHuPD-1, His; PD1; CD279; PDCD1

Human

HEK293

PD-1 Protein, Human (143a.a, HEK293, His)当与T细胞受体的配体PD-L1或PD-L2结合时，抑制T细胞受体的激活信号。

HY-P7398

PD-L1 Protein, Human (HEK293, His) 重组人 PD-L1, His (HEK293 表达) rHuPD-L1, His; Programmed death ligand 1; CD274; B7-H1	Human	HEK293
PD-L1 Protein, Human (HEK293, His)在妊娠、组织移植、自身免疫性疾病和肝炎等疾病状态下，对免疫系统的适应性起着重要的抑制作用。

PD-L1 Protein, Human (HEK293, His)

重组人 PD-L1, His (HEK293 表达)

rHuPD-L1, His; Programmed death ligand 1; CD274; B7-H1

Human

HEK293

PD-L1 Protein, Human (HEK293, His)在妊娠、组织移植、自身免疫性疾病和肝炎等疾病状态下，对免疫系统的适应性起着重要的抑制作用。

HY-P70737

FGL1 Protein, Human (HEK293, His)

Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

Human

HEK293

HY-P70679

IDO Protein, Human (His)

Indole 2; 3-dioxygenase; Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO

Human

E. coli

HY-P70807

PVR/CD155 Protein, Human (HEK 293, His) Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS	Human	HEK293
PVR/CD155 Protein, Human (HEK 293, His)是一种在 HEK 293 细胞中表达的，N 末端有 His 标签的重组人PVR。PVR, Human 在癌细胞的侵袭和迁移中起作用。

PVR/CD155 Protein, Human (HEK 293, His)

Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS

Human

HEK293

PVR/CD155 Protein, Human (HEK 293, His)是一种在 HEK 293 细胞中表达的，N 末端有 His 标签的重组人PVR。PVR, Human 在癌细胞的侵袭和迁移中起作用。

HY-P7399

PD-L2 Protein, Human (HEK293, Fc) 重组人 PD-L2，Fc 嵌合体 (HEK293 表达) rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273	Human	HEK293
PD-L2 Protein, Human (HEK293, Fc)是 PD-1 的另一个配体，和PD-1相互作用，负调控T细胞增殖，细胞因子的产生和细胞毒性。

PD-L2 Protein, Human (HEK293, Fc)

重组人 PD-L2，Fc 嵌合体 (HEK293 表达)

rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273

Human

HEK293

PD-L2 Protein, Human (HEK293, Fc)是 PD-1 的另一个配体，和PD-1相互作用，负调控T细胞增殖，细胞因子的产生和细胞毒性。

HY-P70010

CD73/5'-Nucleotidase Protein, Human (521a.a, HEK293, His)

rHu5'-nucleotidase/CD73, His; 5'-Nucleotidase; 5'-NT; Ecto-5'-Nucleotidase; CD73; NT5E; NT5; NTE

Human

HEK293

HY-P70525

PD-1 Protein, Human (HEK293, mFc)

Programmed cell death protein 1; hPD-1; PDCD1; CD279

Human

HEK293

HY-P70547

PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc)

Programmed cell death 1; PD-1; PD1

Cynomolgus

HEK293

HY-P70651

B7-1/CD80 Protein, Human (208a.a, HEK293, His)

CD80; Activation B7-1 antigen; B7; BB1; CD28LG1; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80

Human

HEK293

HY-P70652

CD276/B7-H3 Protein, Human (433a.a, HEK 293, His)

CD276; B7H34Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule

Human

HEK293

HY-P70657

PD-L1 Protein, Human (HEK293, mFc)

Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1; Programmed Death Ligand 1; B7 Homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1

Human

HEK293

HY-P70672

PD-L1 Protein, Human (221a.a, HEK293, Fc)

Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1; Programmed Death Ligand 1; B7 Homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1

Human

HEK293

HY-P70684

CTLA-4 Protein, Human (126a.a, HEK293, His)

Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4

Human

HEK293

HY-P70691

CTLA-4 Protein, Human (HEK293, GST) Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4	Human	HEK293
CTLA-4 Protein, Human (HEK293, GST)是一种 T 细胞免疫功能的负调节剂。

CTLA-4 Protein, Human (HEK293, GST)

Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4

Human

HEK293

CTLA-4 Protein, Human (HEK293, GST)是一种 T 细胞免疫功能的负调节剂。

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Inhibitory Checkpoint Molecules (抑制性免疫检查点)

Inhibitory Checkpoint Molecules 重组蛋白 (344)