1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. ROR

ROR

The retinoic acid-related orphan receptor (ROR) subgroup of nuclear receptors consists of three members, RORα, -β and -γ (NR1F1-3 or RORA-C). RORs regulate several important physiological processes and have been implicated in a number of pathologies. RORα is critical for cerebellar development and bone formation, while RORβ regulates functions in the brain and retina. RORγ plays a key role in lymph node development and thymopoiesis. Furthermore, both RORα and RORγ are involved in regulating various metabolic pathways, inflammatory responses and immune functions, including Th17 cell differentiation.

The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. RORα/γ are members of the nuclear hormone receptor superfamily, which contains a signature type II zinc finger DNA binding motif and a hydrophobic ligand binding pocket.

ROR 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-10626
    T0901317 Antagonist 99.91%
    T0901317 是口服有效且高度选择性的 LXR 激动剂,对 LXRα 的 EC50 为 20 nM。T0901317 激活 FXREC50 为 5 μM。T0901317 是 RORαRORγ 双重反向激动剂,Ki 值分别为 132 nM 和 51 nM。T0901317 诱导细胞凋亡 (apoptosis),并抑制低密度脂蛋白 (LDL) 受体缺失小鼠动脉粥样硬化的发展。
  • HY-N0155
    Nobiletin Agonist 99.04%
    Nobiletin 是一种来自柑橘皮的聚甲氧基黄酮,可改善记忆力丧失,是一种 RORs 激动剂。Nobiletin 可以降低分化的 C2C12 肌管中的 ROS 的水平,并具有抗炎和抗癌特性,包括抗血管生成,抗增殖,抗转移和诱导细胞凋亡。
  • HY-14413
    SR3335 Antagonist 99.43%
    SR3335 (ML 176) 是选择性的 RORα 反向激动剂,可直接结合 RORα,Ki为 220 nM。
  • HY-14422
    SR1078 Agonist 99.67%
    SR1078 是一种视黄酸受体相关孤儿受体 (RORα/RORγ) 激动剂。SR1078 直接与 RORα 和 RORγ 的配体结合区结合,提高了这些受体的转录活性,从而刺激了 RORα/γ 靶基因的转录。
  • HY-13421
    SR1001 Inhibitor 99.84%
    SR1001 是选择性的 RORαRORγt 反向激动剂,Ki 分别为 172 和 111 nM。
  • HY-12776
    GSK805 Inhibitor
    GSK805 是一种有效,生物可利用的,CNS 穿透性的 RORγt 抑制剂。
  • HY-101454
    SR0987 Agonist 99.56%
    SR0987是SR1078 的一个类似物,是 RORγt 的一个激动剂,其 EC50 值为800 nM。SR0987 可上调IL17 的表达且抑制PD-1 的表达。
  • HY-125801
    3-Oxo-5β-cholanoic acid Inhibitor >98.0%
    3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid),胆汁酸代谢产物,通过直接与关键转录因子RORγt (Kd=1.13 μM) 结合抑制 TH17 细胞分化。
  • HY-117819
    TMP920 Antagonist 99.88%
    TMP920 是一个高效、选择性的 RORγt 拮抗剂。TMP920 抑制 RORγt 结合 SRC1 肽的 IC50 值为 0.03 μM。
  • HY-N2253
    Neoruscogenin Agonist
    Neoruscogenin 是甾体 sapogenin 家族的成员,是可生物利用得,有效且高亲和力的核受体 RORα (NR1F1) 的激动剂。
  • HY-100084
    Methyl-3β-hydroxycholenate Modulator
    Methyl-3β-hydroxycholenate 是一种 ROR gamma 调节剂,详细信息请参考专利文献 US20110263046 A1 中的 figure 2。
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