1. Signaling Pathways
  2. Autophagy
  3. ULK

ULK (UNC-51样激酶)

The ULK (UNC51-like) enzymes are a family of mammalian kinases that have critical roles in autophagy and development. The ULK family of kinases comprises 5 genes in mammals: ULK1 through ULK4 and STK36. In mammals, ULK1 and ULK2 have been shown to be necessary for the proper autophagy induction and contribute to various developmental, physiological, and pathological processes.

The serine/threonine-protein kinases ULK1 and ULK2 are evolutionarily conserved serine/threonine kinase orthologs of the yeast autophagy related (Atg) family member Atg1, that have redundant roles in the regulation of autophagy. Autophagy targets long-lived proteins or organelles for degradation in lysosomes, and the products of this process are then recycled for other cellular pathways. The canonical ULK/Atg1 complex is composed of ULK1, ATG13, RB1CC1/FIP200/ATG17, and ATG101. It initiates autophagosome formation, at least in part by phosphorylating components of the autophagy-inducing class III phosphatidylinositol 3-kinase complex (e.g., PI3K3C/Vps34, PIK3R4/Vps15, BECN1/Vps30/ATG6, ATG14). ULK/Atg1 also promotes membrane recycling via ATG9. Consistent with the established role of ULK1/2 in autophagy, disrupting ULK1 expression in mice results in a defect in autophagy-mediated clearance of mitochondria during red blood cell maturation, and mice lacking both ULK1 and ULK2 expression die shortly after birth due to a defect in glycogen metabolism, which is similar to other autophagy-defective mice.

ULK 亚型特异性产品:

  • ULK1

  • ULK2

ULK 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-13018
    MRT67307 Inhibitor 99.34%
    MRT67307 是 IKKεTBK-1 的双抑制剂,IC50 分别为 160 和 19 nM。MRT67307 也可抑制 ULK1ULK2IC50 分别为 45 和 38 nM。MRT67307 还抑制细胞自噬 (autophagy)。
  • HY-100006A
    MRT68921 dihydrochloride Inhibitor 99.38%
    MRT68921 dihydrochloride 是 ULK1ULK2 有效的抑制剂,IC50 值分别为 2.9 nM和 1.1 nM。
  • HY-114490
    ULK-101 Inhibitor 99.98%
    ULK-101 是一个有效的、选择性的ULK1 抑制剂,其在体外测得的对 ULK1和 ULK2 的 IC50 值分别为 1.6 nM 和 30 nM。ULK-101 抑制自噬,使癌细胞对营养胁迫敏感。
  • HY-115570
    GW406108X Inhibitor ≥98.0%
    GW406108X 是特异性的 Kif15 (Kinesin-12) 抑制剂,IC50 为 0.82 uM。GW406108X 是一种有效的自噬 (autophagy) 抑制剂, ATP 竞争性抑制 ULK1pIC50 为 6.37 (427 nM)。GW406108X 抑制 ULK1 和自噬,而不影响 mTOR 或 AMPK 活性。
  • HY-100006
    MRT68921 Inhibitor
    MRT68921 是 ULK1ULK2 有效的抑制剂,IC50 值分别为 2.9 nM 和 1.1 nM。
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