1. Signaling Pathways
  2. Autophagy
  3. ULK


ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

ULK Isoform Specific Products:

  • ULK1

  • ULK2

ULK 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-16966
    SBI-0206965 Inhibitor 98.76%
    SBI-0206965 是一种强效, 选择性和细胞渗透性自噬激酶 ULK1 抑制剂, 抑制 ULK1 和 ULK2 激酶活性, IC50 值分别为 108 nM 和 711 nM。
  • HY-100006A
    MRT68921 dihydrochloride Inhibitor 99.38%
    MRT68921 dihydrochloride 是 ULK1ULK2 有效的抑制剂,IC50 值分别为 2.9 nM和 1.1 nM。
  • HY-13018
    MRT67307 Inhibitor 99.34%
    MRT67307 是 IKKεTBK-1 的双抑制剂,IC50 分别为 160 和 19 nM。MRT67307 也可抑制 ULK1ULK2IC50 分别为 45 和 38 nM。MRT67307 还抑制细胞自噬 (autophagy)。
  • HY-114490
    ULK-101 Inhibitor 99.98%
    ULK-101 是一个有效的、选择性的ULK1 抑制剂,其在体外测得的对 ULK1和 ULK2 的 IC50 值分别为 1.6 nM 和 30 nM。ULK-101 抑制自噬,使癌细胞对营养胁迫敏感。
  • HY-101923B
    LYN-1604 dihydrochloride Activator 98.73%
    LYN-1604 dihydrochloride 是一种有效的 UNC-51 样激酶 1 (ULK1) 激活剂,EC50 值为 18.94 nM。LYN-1604 可用于三阴性乳腺癌 (TNBC) 的研究。
  • HY-115570
    GW406108X Inhibitor
    GW406108X 是特异性的 Kif15 (Kinesin-12) 抑制剂,IC50 为 0.82 uM。GW406108X 是一种有效的自噬 (autophagy) 抑制剂, ATP 竞争性抑制 ULK1pIC50 为 6.37 (427 nM)。GW406108X 抑制 ULK1 和自噬,而不影响 mTOR 或 AMPK 活性。
  • HY-124729
    BL-918 Activator 98.36%
    BL-918 是一种具有口服活性 UNC-51 样激酶 1 (ULK1) 激活剂,EC50 为 24.14 nM。BL-918 通过靶向 ULK 复合物发挥其细胞保护性自噬作用。BL-918 有用于帕金森氏病 (PD) 的潜力。
  • HY-124729A
    (Rac)-BL-918 Activator 98.03%
    (Rac)-BL-918 是BL-918 的消旋体。BL-918 是 ULK1 的有效激活剂,可诱导细胞保护性自噬,用于帕金森病的研究。
Isoform Specific Products

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