1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Early 2 Factor (E2F)

Early 2 Factor (E2F) 

The Early 2 Factors (E2Fs) are a family of eight winged-helix transcription factors that are key to regulating cell cycle progression from G1 to S phase among other functions. E2F1, E2F2, and E2F3a are expressed in early G1 through S phase and are believed to promote S phase initiation by activating genes involved in the G1 to S phase transition18. E2F3b, E2F4, E2F6, E2F5, E2F7, and E2F8 act as repressors and are expressed later in the cell cycle. E2Fs participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism.

Early 2 Factor (E2F) 相关产品 (2):

目录号 产品名 作用方式 纯度
  • HY-16667
    HLM006474 Inhibitor 98.43%
    HLM006474 是一种广谱的 E2F 抑制剂,在 A375 细胞中,可抑制 E2F4 DAN 结合,IC50 值为 29.8 µM。
  • HY-117857
    MRT00033659 Inhibitor 99.18%
    MRT00033659 是一种有效的广谱激酶抑制剂,抑制 CK1 (对 CK1δ:IC50=0.9 µM) 和 CHK1 (IC50=0.23 µM)。MRT00033659 是一种吡唑并吡啶类似物,可以诱导 p53 途径活化和 E2F-1 不稳定。