1. Signaling Pathways
  2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. REV-ERB


REV-ERB is a member of the nuclear receptor superfamily consisting of two similar proteins: REV-ERBα and REV-ERBβ. REV-ERBα and REV-ERBβ, are encoded by Nr1d1 and Nr1d2, and link circadian rhythms and metabolism. REV-ERBs lack the canonical NR activation domain, and thus function as a transcriptional repressor. Like other NRs, REV-ERBs can be regulated by ligands, including naturally occurring heme (22, 23), which modulate their repressive activity. Two REV-ERB molecules, usually present as a dimer, compete with retinoic acid receptor-related orphan receptor (ROR) for the binding to the ROR response element DNA sequence (RORE) region. REV-ERB is involved in the regulation of many physiological processes, from circadian rhythm, to immune function and metabolism. Accordingly, REV-ERB has been considered as a promising, but difficult drug target for the treatment of numerous diseases.

REV-ERB 相关产品 (10):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14415
    SR8278 Antagonist 99.76%
    SR8278 是一种 REV-ERBα 拮抗剂,可抑制 REV-ERBα 的转录,其 EC50 值为 0.47 μM。SR8278 用于调节生物体内代谢,研究生物节律。SR8278 还可用于杜氏肌营养不良和阿尔茨海默病的研究。
  • HY-14414
    GSK4112 Inhibitor ≥98.0%
    GSK4112 (SR6452) 是 Rev-erbα 的激动剂,EC50 值为 0.4 μM。GSK4112 可作为一种化学工具来探究 Rev-erbα 在转录抑制、昼夜节律生物学调节和代谢途径中的功能。
  • HY-148711
    STL1267 Activator 99.86%
    STL1267 是一种有效的可穿过血脑屏障的 REV-ERB 激动剂,对 REV-ERBα 的Ki 值为 0.16 µM。STL1267 没有表现出细胞毒性。STL1267 抑制 BMAL1 的基因表达。
  • HY-16988
    SR9011 98.97%
    SR9011 是一种 REV-ERBα/β 激动剂,作用于 REV-ERBα 和 REV-ERBβ,IC50s 分别为 790 nM 和 560 nM。
  • HY-117516
    SR10067 Agonist ≥99.0%
    SR10067 是一种强效、选择性和脑渗透性 REV-ERB 激动剂。SR10067 对 Rev-Erbβ 和 Rev-Erbα 具有高亲和力, IC50 值分别为 160 nM 和 170 nM。 SR10067 可用于代谢疾病和神经精神疾病的研究。
  • HY-156458
    SR-29065 Agonist
    SR-29065是一种选择性 REV-ERBα 激动剂,可用于自身免疫性疾病研究。
  • HY-163136
    Autophagy/REV-ERB-IN-1 Inhibitor
    Autophagy/REV-ERB-IN-1 是自噬REV-ERB的双重抑制剂。 Autophagy/REV-ERB-IN-1 具有抗肿瘤活性,在 BTB-474 细胞上的 CC50 值为 2.3 μM。
  • HY-163136A
    Autophagy/REV-ERB-IN-1 hydrochloride Inhibitor
    Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) 是一种自噬和 REV-ERB 双重抑制剂,具有抗癌活性。Autophagy/REV-ERB-IN-1 (hydrochloride) 提高了阻断自噬的效力,增强了对癌细胞的毒性。Autophagy/REV-ERB-IN-1 (hydrochloride) 可用于黑色素瘤的研究。
    Autophagy/REV-ERB-IN-1 hydrochloride
  • HY-148103
    SR12418 99.93%
    SR12418 是一种 REV-ERB 特异性合成配体,对 REV-ERBα 和 REV-ERBβ 的 IC50 值分别为 68 nM 和 119 nM。SR12418 可用于实验性自身免疫性脑脊髓炎 (EAE) 和结肠炎的研究。
  • HY-16988A
    SR9011 hydrochloride 99.39%
    SR9011 hydrochloride 是一种 REV-ERBα/β 激动剂,作用于 REV-ERBα 和 REV-ERBβ,IC50s 分别为 790 nM 和 560 nM。
    SR9011 hydrochloride