1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. BCRP

BCRP (乳腺癌耐药蛋白)

BCRP(breast cancer resistant protein) is an ATP-binding cassette (ABC) transporter, which together with two other ABC efflux drug pumps, namely P-glycoprotein (P-gp, ABCB1) and multidrug resistance-related protein 1 (MRP1, ABCC1) is the most important multidrug resistance protein found in eukaryotic cells including cells in the testis.

Breast cancer resistance protein (BCRP/ABCG2) is known to localize at the blood-brain barrier (BBB) and can significantly restrict xenobiotic permeability in the brain. The objective of this study is to investigate the regulation of BCRP functional expression by peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor primarily involved in lipid metabolism, in a cerebral microvascular endothelial cell culture system (hCMEC/D3), representative of human BBB.

BCRP 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-10010
    Ko 143 Inhibitor 99.79%
    Ko 143 是有效且选择性的 ATP 结合盒亚家族 G 成员 2 (ABCG2/BCRP) 抑制剂。Ko 143 比 P-gp 和 MRP-1 运输蛋白高出 200 倍的选择性。
  • HY-50879
    Elacridar Inhibitor 99.80%
    Elacridar (GF120918) 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
  • HY-N2143
    Fumitremorgin C Inhibitor 98.26%
    Fumitremorgin C是有效,选择性的ABCG2/BRCP抑制剂。
  • HY-19753
    KS176 Inhibitor 99.21%
    KS176是一种选择性的高活性乳腺癌耐药蛋白多药转运通道 (BCRP) 抑制剂(在Pheo A和Hoechst检测中IC50值分别为0.59和1.39 μM)。对P-gp和MRP1没有抑制活性。
  • HY-18010
    PCI 29732 Inhibitor 99.68%
    PCI 29732 是一种有效的可逆 BTK 抑制剂,对 BTK、Lck 和 Lyn 的 Kiapp 值分别为 8.2、4.6 和 2.5 nM。PCI 29732 对另一种 Tec 家族激酶 Itk 仅有适度的抑制活性。PCI 29732 通过竞争性结合ABCG2 的 ATP 结合位点来抑制 ABCG2 的功能。
  • HY-136450
    Triclabendazole sulfoxide Inhibitor
    Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。
  • HY-128685
    FD 12-9 Inhibitor
    FD 12-9 是一种类黄酮二聚体,为 P-gpBCRP 的双重抑制剂,EC50 值分别为 285 nM 和 0.9 nM。具有抗胶质细胞瘤活性。
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