1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. DYRK


Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

DYRK 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-N0737A
    Harmine Inhibitor 99.78%
    Harmine 是一种具有抗癌和抗炎活性的天然双特异性酪氨酸磷酸化调节激酶 (DYRK) 抑制剂。Harmine 对 5-HT2A 血清素受体具有高亲和力,Ki 值为 397 nM。
  • HY-12277
    AZ191 Inhibitor 99.98%
    AZ191 是 DYRK1B 高效选择性抑制剂,IC50 值 17 nM。
  • HY-100464
    tBID Inhibitor 98.97%
    tBID 是同源结构域相互作用蛋白激酶2 (HIPK2) 的选择性抑制剂,IC50值为 0.33 μM。
  • HY-12838
    Mirk-IN-1 Inhibitor 99.53%
  • HY-U00439A
    Protein kinase inhibitors 1 hydrochloride Inhibitor >98.0%
    Protein kinase inhibitors 1 hydrochloride 是一种有效的 HIPK2 抑制剂,对 HIPK1 和 HIPK2 的 IC50 值分别为 136 和 74 nM,对 HIPK2 的 Kd 值为 9.5 nM。
  • HY-111380
    EHT 5372 Inhibitor 98.07%
    EHT 5372 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂,其 IC50 值分别为 0.22,0.28 nM。
  • HY-105309
    GSK-626616 Inhibitor 99.58%
    GSK-626616 是一种有效的口服生物可利用的 DYRK3 抑制剂,IC50为 0.7 nM。GSK-626616 以相似的效力抑制 DYRK 家族的其他成员 (例如,DYRK1A和DYRK2),GSK-626616 是潜在的治疗贫血的方法。
  • HY-13455A
    LDN-192960 hydrochloride Inhibitor >98.0%
    LDN-192960 hydrochloride 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
  • HY-15838
    ID-8 Inhibitor 99.71%
  • HY-U00439
    Protein kinase inhibitors 1 Inhibitor >99.0%
    Protein kinase inhibitors 1 是一个新型的 HIPK2 抑制剂,其 IC50 值为 74 nM, Kd 值为 9.5 nM。
  • HY-13455
    LDN-192960 Inhibitor 99.56%
    LDN-192960 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
  • HY-128758
    DYRKs-IN-1 Inhibitor
    DYRKs-IN-1 (例183) 是一种有效的 DYRKs (双特异性酪氨酸磷酸化调节激酶) 抑制剂,对 DYRK1B 和 DYRK1A 的 IC50 分别为 9 nM 和 5 nM。DYRKs-IN-1 有抗肿瘤活性。
  • HY-128759
    DYRKs-IN-2 Inhibitor
    DYRKs-IN-2 (例132) 是一种有效的 DYRKs (双特异性酪氨酸磷酸化调节激酶) 抑制剂,对 DYRK1B 和 DYRK1A 的 IC50 分别为 9 nM 和 5 nM。DYRKs-IN-2 有抗肿瘤活性。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.