1. 重组蛋白
  2. Enzymes & Regulators
  3. Matrix Metalloproteinases

Matrix Metalloproteinases  (基质金属蛋白酶)

基质金属蛋白酶 (MMPs),又称基质金属多肽酶或matrixins,它是一类锌依赖性的蛋白水解酶,可降解细胞外基质 (ECM) 中的多种蛋白。MMPs 属于金属蛋白酶的 metzincin超家族,其他成员如 astacins、serralysins、reprolysins、adamalysins 或 ADAMs。MMPs 由 24 个人类基因和 23 个小鼠基因编码。 MMP 家族至少可以分为六个亚家族:(1) 胶原酶; (2) 明胶酶,(3) 溶血素,(4) 基质溶素,(5) 膜型MMPs,(6) 其他 MMPs。 MMPs 的典型结构包括 N 端酶原前肽结构域、金属蛋白酶催化结构域、可变长度的连接区和 C 端类血凝蛋白结构域。 所有MMPs 都是作为原酶产生的,需要在生理条件下进行蛋白裂解,以促进前肽结构域的释放 (酶原激活),并产生成熟的基质金属蛋白酶。MMPs 在许多生物学过程中发挥了关键作用,如胚胎发生、正常组织重塑、伤口愈合和血管生成,以及在疾病中也发挥了重要作用,如动脉粥样硬化、关节炎、癌症和组织溃疡。

Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are a family of zinc-dependent proteolytic enzymes that degrade various proteins in the extracellular matrix (ECM). MMPs belong to the large metzincin superfamily of metalloproteases, like the astacins, serralysins, reprolysins, and adamalysins or disintegrin metalloproteinases (ADAMs). MMPs are encoded by 24 human (including a duplicated MMP-23 gene) and 23 mouse genes. The MMP family can be divided into at least six subfamilies: (1) collagenases; (2) gelatinases, (3) stromelysins, (4) matrilysins, (5) MMP membrane-type (MT)-MMPs, and (6) other MMPs. A typical MMPs consists of an N-terminal zymogenic propeptide domain (~80 amino acids), a metal-dependent catalytic domain (~170 amino acids), a linker region (~15-65 amino acids), and a C-terminal hemopexin-like domain (~200 amino acids). All MMPs are synthesized as proenzymes and require a proteolytic cleavage under physiological conditions to promote the release of the propeptide domain (zymogen activation) and generate mature MMPs. MMPs play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration.

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