1. 重组蛋白
  2. Ubiquitin Related Proteins
  3. Ubiquitin/UBLs

Ubiquitin/UBLs  (泛素 & 泛素样蛋白)

Ubiquitin (Ub) is an evolutionarily conserved, heat-stable small protein containing 76 amino acids that is ubiquitously expressed in eukaryotic cells. It is highly conserved with little variance in animal species from insects to humans. Only 2-3 amino-acid residues vary between the yeast and plant and the yeast and human protein. Ubiquitin serves as a post-translational modifier of cellular substrates. Ubiquitin can be reversibly attached onto other proteins as a monomer or as a poly-ubiquitin chain of diverse structural topologies, and provides exceptionally flexible control over processes from cell division to cell death, from gene transcription to protein degradation, by dictating protein interaction, function, and turnover. Ubiquitin-like proteins (UBLs) encompass a family of proteins that share structural and evolutionary relationships with ubiquitin. The UBLs, including ubiquitin itself, share the same basic three-dimensional core structure, the β-grasp fold. Most UBLs are conjugated to proteins via an enzymatic cascade that resembles ubiquitylation, and many of their components are related to those involved in ubiquitylation. The UBLs family includes 10 members: small ubiquitin modifier (SUMO), neural precursor cell expressed developmentally downregulated 8 (NEDD8) or Related to Ubiquitin 1 (RUB 1) in yeast, Ubiquitin-Related Modifier-1 (URM1), Ubiquitin-fold Modifier 1 (UFM1), autophagy-related proteins 8 and 12 (ATG8 and ATG12), interferon-stimulated gene 15 (ISG15), human leukocyte antigen (HLA)-F adjacent transcript 10 (FAT10), fan ubiquitin-like protein 1 (FUB1), and histone mono-ubiquitination 1 (HUB1). Ubiquitin and UBLs are critical regulators of complex cellular processes such as the cell cycle, DNA repair, transcription, chromatin remodeling, signal translation, and protein degradation.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P70149
    ISG15/UCRP Protein, Human (His)

    rHuISG15/UCRP, His; Ubiquitin-Like Protein ISG15; Interferon-Induced 15 kDa Protein; Interferon-Induced 17 kDa Protein; IP17; Ubiquitin Cross-Reactive Protein; hUCRP; ISG15; G1P2; UCRP

    Human E. coli
  • HY-P70843
    NEDD8 Protein, Human

    Neural precursor cell expressed developmentally down-regulated protein 8; NEDD8; Neddylin; Ubiquitin-like protein Nedd8

    Human E. coli
  • HY-P70861
    GABARAP Protein, Human (GST)

    GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP

    Human E. coli
  • HY-P70913
    GABARAPL1/GEC-1 Protein, Human (His)

    Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1; Early Estrogen-Regulated Protein; GABA(A) Receptor-Associated Protein-Like 1; Glandular Epithelial Cell Protein 1; GEC-1; GABARAPL1; GEC1

    Human E. coli
  • HY-P70974
    SUMO2 Protein, Human (His)

    Small Ubiquitin-Related Modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-Like Protein SMT3A; Smt3A; SUMO2; SMT3A; SMT3H2

    Human E. coli
  • HY-P70997
    SUMO1 Protein, Human (His)

    Small Ubiquitin-Related Modifier 1; SUMO-1; GAP-Modifying Protein 1; GMP1; SMT3 Homolog 3; Sentrin; Ubiquitin-Homology Domain Protein PIC1; Ubiquitin-Like Protein SMT3C; Smt3C; Ubiquitin-Like Protein UBL1; SUMO1; SMT3C; SMT3H3; UBL1

    Human E. coli
  • HY-P71101
    UBB Protein, Human

    Polyubiquitin-B; UBB

    Human E. coli
  • HY-P71346
    SUMO3 Protein, Human (HEK293, His)

    Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A

    Human HEK 293
  • HY-P71681
    FAU Protein, Human (GST)

    FAU; Ubiquitin-like protein FUBI

    Human E. coli
  • HY-P72639
    GABARAP Protein, Human (His, Fc)

    GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP

    Human E.coli
  • HY-P76944
    GCAP1 Protein, Human (sf9)

    Guanylyl cyclase-activating protein 1; Guanylate cyclase activator 1A; C6orf131; GCAP; GUCA1; GUCA1A

    Human Sf9 insect cells
目录号 产品名 作用方式 纯度