1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Mps1


Monopolar spindle 1 (Mps1/TTK) is a serine/threonine kinase conserved from yeast to human. It has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

MPS1, a dual specificity protein kinase, is also one of the main components of the SAC and ensures cells do not progress from metaphase to anaphase until the kinetochores are properly attached to the microtubules and under the appropriate tension at the metaphase plate. Cancer cells heavily rely on MPS1 to cope with aneuploidy resulting from aberrant numbers of chromosomes. The kinase has been found to be upregulated in a large number of tumor types. Mps1 is an attractive oncology target due to its high expression level in cancer cells as well as the correlation of its expression levels with histological grades of cancers.

Mps1 相关产品 (13):

目录号 产品名 作用方式 纯度
  • HY-12859
    BAY1217389 Inhibitor 99.94%
    BAY 1217389是具有高效性和选择性的(MPS1)激酶抑制剂,IC50值小于10 nM。
  • HY-14710
    AZ3146 Inhibitor 99.92%
    AZ3146 是一种有效的选择性的 Mps1 抑制剂,作用于 Mps1CatIC50 为 35 nM。
  • HY-13298
    Mps1-IN-1 Inhibitor 99.37%
    Mps1-IN-1 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50Kd 值分别为 367 nM 和 27 nM。
  • HY-112162
    BOS-172722 Inhibitor 99.44%
    BOS-172722 是单极纺锤体 1 (MPS1) 检查点的抑制剂,其 对MPS1 (1 mM ATP) 和P-MPS1 的 IC50 值分别为 11 nM 和 63 nM。BOS-172722 可用于多种乳腺癌的研究。
  • HY-12660
    MPI-0479605 Inhibitor 99.13%
    MPI-0479605 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50 值为 1.8 nM。
  • HY-144308
    RMS-07 Inhibitor
    RMS-07 是 Monopolar Spindle Kinase 1 (MPS1/TTK) 的共价抑制剂,其IC50 值为 13.1 nM。RMS-07靶向激酶结构域的半胱氨酸。
  • HY-12382
    NMS-P715 Inhibitor 99.58%
    NMS-P715 是一种选择性的,ATP 竞争性的 MPS1 抑制剂,IC50 值为 182 nM。
  • HY-12858
    Empesertib Inhibitor ≥98.0%
    Empesertib (BAY 1161909) 是一种有效的 Mps1 抑制剂,IC50 值 <1 nM。
  • HY-13994
    Mps1-IN-2 Inhibitor 98.15%
    Mps1-IN-2 是一种有效的,选择性的,ATP 竞争性的 Mps1/Plk1 双重抑制剂,对 Mps1 的 IC50Kd 值分别为 145 nM 和 12 nM,对 Plk1 的 Kd 值为 61 nM。
  • HY-12401
    Mps1-IN-3 Inhibitor ≥98.0%
    Mps1-IN-3 是一种有效的,选择性的 MPS1 抑制剂,IC50 值为 50 nM。
  • HY-12603
    CCT251455 Inhibitor 98.26%
    CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1 (MPS1) 抑制剂,IC50 值为3 nM。
  • HY-110115
    TC-Mps1-12 Inhibitor ≥99.0%
    TC-Mps1-12 是一种高效、选择性的 Mps1 抑制剂,其 IC50 值为 6.4 nM。
  • HY-110347
    Mps1-IN-1 dihydrochloride Inhibitor
    Mps1-IN-1 dihydrochloride 是一种有效的,ATP 竞争性 Mps1 激酶抑制剂,IC50 为 367 nM。Mps1-IN-1 dihydrochloride 抑制 Mps1 有丝分裂激酶活性并沉默纺锤体组装检查点 (SAC) 功能。Mps1-IN-1 dihydrochloride 降低癌细胞和“正常”细胞的活力。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.