1. Signaling Pathways
  2. GPCR/G Protein
  3. EBI2/GPR183

EBI2/GPR183 

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

EBI2/GPR183 相关产品 (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113962
    7α,25-Dihydroxycholesterol Agonist ≥99.0%
    7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。
    7α,25-Dihydroxycholesterol
  • HY-12336
    NIBR189 Inhibitor 99.41%
    NIBR189 是 EBI2 (Epstein-Barr virus-induced gene 2) 的拮抗剂。NIBR189 抑制人和老鼠的 EBI2, IC50 值分别为 11 和 16 nM。NIBR189 可用于自身免疫病的研究。
    NIBR189
  • HY-101192
    GSK682753A Inhibitor 99.56%
    GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为 53.6 nM。
    GSK682753A
  • HY-116814
    ML401 Antagonist 99.93%
    ML401 是一种有效的化学探针,选择性地拮抗 EBI2 (也称为 GPR183),IC50 值为1.03 nM。ML401 在趋化性分析中显示活性 (IC50=6.24 nM)。ML401 表现出良好的稳定性,且无细胞毒性。
    ML401
  • HY-147222
    SAE-14 Antagonist 98.26%
    SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂,IC50值为 28.5 nM,可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导, IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。
    SAE-14
  • HY-162011
    GPR183 antagonist-2 Antagonist 99.96%
    GPR183 antagonist-2 (化合物 32) 是一种选择性 GPR183 拮抗剂,具有良好的水溶性和优异的药代动力学特性。GPR183 antagonist-2 以剂量依赖性方式显著降低了胶原诱导的关节炎 (CIA) 小鼠模型中爪子和关节的肿胀以及促炎细胞因子 (MCP-1,MMPs 和 VEGF) 的基因表达。GPR183 antagonist-2 可用于自身免疫性疾病的研究。
    GPR183 antagonist-2
  • HY-157939
    GPR183 antagonist-3 Antagonist
    GPR183 antagonist-3 (compound 33) 是一种口服活性 GPR183 拮抗剂,其 IC50 值为 8.7 μM。GPR183 antagonist-3 在单核细胞中表现出较强的体外抗迁移和抗炎活性,可改善葡聚糖硫酸钠诱导的实验性结肠炎的病理症状。
    GPR183 antagonist-3
  • HY-400897
    7α,25-Dihydroxycholesterol intermediate-1
    7α,25-Dihydroxycholesterol intermediate-1 是合成 7α,25-Dihydroxycholesterol (HY-113962) 的中间体,7α,25-Dihydroxycholesterol (7α,25-OHC) 可作为靶向孤儿 GPCR 受体 EBI2 (GPR183) 的配体,用于合成对应的 PROTEACs。
    7α,25-Dihydroxycholesterol intermediate-1
  • HY-113962S
    7α,25-Dihydroxycholesterol-d6
    7α,25-Dihydroxycholesterol-d6 是 7α,25-Dihydroxycholesterol 的氘代物。7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450
    7α,25-Dihydroxycholesterol-d<sub>6</sub>