1. Signaling Pathways
  2. GPCR/G Protein
  3. EBI2/GPR183

EBI2/GPR183 

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

EBI2/GPR183 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-101192
    GSK682753A Inhibitor 99.84%
    GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为 53.6 nM。
  • HY-113962
    7α,25-Dihydroxycholesterol Agonist >99.0%
    7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。
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