1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Smo


Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways.

The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.

Smo 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-17024
    Cyclopamine Inhibitor ≥98.0%
    Cyclopamine 是 Hedgehog 通路的拮抗剂,在细胞实验中的 IC50 为 46 nM。Cyclopamine 还是一种选择性的 Smo 抑制剂。
  • HY-12848
    SAG Agonist 99.88%
    SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。
  • HY-15108
    Purmorphamine Activator 99.89%
    Purmorphamine (Shh Signaling Antagonist VI) 是一种平滑受体 (smoothened/Smo receptor) 激动剂,EC50 为 1 μM。
  • HY-12316
    20(S)-Hydroxycholesterol Activator ≥98.0%
    20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂,在以 NIH3T3 细胞的基因转录报告实验中,激活 hedgehog (Hh) 信号通路的 EC50 值为 3 μM。
  • HY-B0877
    Halcinonide Agonist 99.87%
    Halcinonide (SQ-18566) 是一糖皮质激素,用于研究局部皮肤感染。
  • HY-N0836
    Jervine Inhibitor 99.53%
    Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂,IC50 为 500-700 nM。Jervine 是来自 Veratrum album 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。
  • HY-117407
    ALLO-2 Antagonist 99.58%
    ALLO-2 是有效的 Smo耐药突变体的拮抗剂,在TM3-Gli-Luc细胞中能够抑制Smo激动剂Hh-Ag1.5诱导的荧光素酶表达,其IC50 值为6 nM。
  • HY-131016
    IHR-Cy3 Antagonist
    IHR-Cy3 是一种有效的 Smo 荧光拮抗剂,IC50 为 100 nM。
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