1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Smo

Smo 

Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation.[3] SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

Smo 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-17024
    Cyclopamine Inhibitor 99.97%
    Cyclopamine 是 Hedgehog 通路的拮抗剂,在细胞实验中的 IC50 为 46 nM。Cyclopamine 还是一种选择性的 Smo 抑制剂。
  • HY-15108
    Purmorphamine Activator 99.89%
    Purmorphamine (Shh Signaling Antagonist VI) 是一种平滑受体 (smoothened/Smo receptor) 激动剂,EC50 为 1 μM。
  • HY-12316
    20(S)-Hydroxycholesterol Activator 98.07%
    20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂,在以 NIH3T3 细胞的基因转录报告实验中,激活 hedgehog (Hh) 信号通路的 EC50 值为 3 μM。
  • HY-B0877
    Halcinonide Agonist 99.87%
    Halcinonide (SQ-18566) 是一糖皮质激素,用于研究局部皮肤感染。
  • HY-N0836
    Jervine Inhibitor 99.53%
    Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂,IC50 为 500-700 nM。Jervine 是来自 Veratrum album 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。
  • HY-117407
    ALLO-2 Antagonist 99.58%
    ALLO-2 是有效的 Smo耐药突变体的拮抗剂,在TM3-Gli-Luc细胞中能够抑制Smo激动剂Hh-Ag1.5诱导的荧光素酶表达,其IC50 值为6 nM。
  • HY-131016
    IHR-Cy3 Antagonist
    IHR-Cy3 是一种有效的 Smo 荧光拮抗剂,IC50 为 100 nM。
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