1. Signaling Pathways
  2. Neuronal Signaling
  3. AChE


Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE 相关产品 (76):

Cat. No. Product Name Effect Purity
  • HY-B0034
    Donepezil Hydrochloride Inhibitor 99.97%
    Donepezil (E 2020) 盐酸盐是非竞争性的AChE抑制剂,能穿过血脑屏障,增加皮质中的乙酰胆碱水平。
  • HY-76299
    Galanthamine Inhibitor 99.90%
    Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50 为 500 nM。
  • HY-14566
    Donepezil Inhibitor 99.87%
    Donepezil (E2020 free base) 是 AChE 抑制剂,对 bAChE 和 hAChE 的 IC50 分别为 8.12 nM 和 11.6 nM。
  • HY-17552
    sn-Glycero-3-phosphocholine Activator >98.0%
    sn-Glycero-3-phosphocholine (Choline Alfoscerate) 是脑磷脂生物合成的前体,可提高胆碱在神经组织中的生物利用度。sn-Glycero-3-phosphocholine (Choline Alfoscerate) 对认知功能有显著影响,具有良好的安全性和耐受性,对阿尔茨海默病和痴呆症的治疗有效。
  • HY-B0943
    Malathion Inhibitor >98.0%
  • HY-107569
    Garcinol Inhibitor >98.0%
    Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮,对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性,IC50 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC50=7 μM) 和 p300/CPB 相关因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。
  • HY-B2155
    Acotiamide monohydrochloride trihydrate Inhibitor 99.28%
    Acotiamide monohydrochloride trihydrate 是一种口服活性和一流的用于治疗功能性消化不良的胃肠动力药。Acotiamide monohydrochloride trihydrate 通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶 (AChE) 抑制作用增强肠神经元释放的乙酰胆碱,从而增强胃排空和胃部适应性。
  • HY-103374
    Phenserine Inhibitor >99.0%
    Phenserine ((-)-Eseroline phenylcarbamate) 是 Physostigmine 的衍生物,是一种有效的,非竞争性,长效和选择性的 AChE 抑制剂。Phenserine 可减少 β-淀粉样蛋白前体蛋白 (APP) 和 β-淀粉样肽 () 的形成。Phenserine 可改善认知能力并减轻阿尔茨海默氏病的进展。
  • HY-B2244
    Tacrine hydrochloride hydrate Inhibitor 99.98%
    Tacrine hydrochloride hydrate 是乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,其 IC50 值分别为 31 nM 和 25.6 nM。
  • HY-17368
    Rivastigmine Inhibitor 99.39%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-17388
    (±)-Huperzine A Inhibitor >98.0%
    (±)-Huperzine A 是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-17387
    (-)-Huperzine A Inhibitor >98.0%
    (-)-Huperzine A (Huperzine A) 是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-A0009
    Galanthamine hydrobromide Inhibitor 99.93%
    Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。
  • HY-B0949
    Protriptyline hydrochloride Inhibitor 99.91%
    Protriptyline hydrochloride 是一种三环抗抑郁药(TCA),含有一个仲胺,治疗抑郁和ADHD。与其他抗抑郁药相比是独一无二的,Protriptyline是激励代替镇静,并且有时用于嗜睡症,实现促醒效果。
  • HY-B0207A
    Pyridostigmine bromide Inhibitor >98.0%
    Pyridostigmine bromide 是可逆的胆碱酯酶抑制剂。
  • HY-N0342
    Scopoletin Inhibitor 99.54%
    Scopoletin 是一种乙酰胆碱酯酶 (AChE) 抑制剂。
  • HY-N0285
    Imperatorin Inhibitor
    Imperatorin 是一种有效的 NO synthesis 抑制剂,IC50 为 9.2 μmol,也是 BChE 抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1 的微弱激动剂,EC50 为 12.6±3.2 μM。
  • HY-11017
    Rivastigmine tartrate Inhibitor 99.45%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-B0882
    Edrophonium chloride Inhibitor >98.0%
    Edrophonium chloride是乙酰胆碱酯酶可逆性抑制剂。
  • HY-N0810
    Timosaponin AIII 98.88%
    Timosaponin AIII 能够抑制 乙酰胆碱酯酶 (AChE) 的活性,其 IC50 值为 35.4 μM。
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