1. Signaling Pathways
  2. Autophagy
  3. Atg4


Autophagy-related 4

Atg4 is the sole cysteine protease among dozens of Atg proteins and functions as an essential factor in the Atg8 conjugation system. While only one Atg4 is present in yeast, there are four Atg4 homologues (Atg4A, Atg4B, Atg4C, and Atg4D) in human and in mouse with different substrate specificities and catalytic efficiencies. Atg4 cleaves Atg8 at the peptide bond on the glycine residue at the C-terminus, thus allowing the conjugation of Atg8 to phosphatidylethanolamine (PE) with the participation of other autophagy molecules. Atg4 can also serve as a deconjugating enzyme, which cleaves the amide bond of the conjugated Atg8 and releases it from the autophagosomal membrane. The latter step is important for reusing Atg8 upon autophagy completion. Moreover, this deconjugation process may also occur on isolation membrane, which would positively or negatively affect membrane formation.

Atg4 相关产品 (1):

目录号 产品名 作用方式 纯度
  • HY-125169
    NSC 185058 Inhibitor 99.52%
    NSC 185058 是一种 ATG4B 抑制剂。ATG4B 是一种主要的半胱氨酸蛋白酶 (cysteine protease)。NSC185058 抑制 ATG4B 从而显著减弱自噬 (autophagic) 活性。