1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. GlyT

GlyT

Glycine transporters (GlyTs) belong to a large family of Na+/Cl--dependent transporter proteins that includes transporters for monoamines [5-hydroxytryptamine (serotonin), noradrenaline and dopamine] and γ-aminobutyric acid. GlyT-mediated glycine uptake is energetically coupled with the transmembrane sodium gradient maintained by the Na+/K+-ATPase.

GlyT1 is essential for regulating glycine concentrations at synaptic receptors.

GlyT2 is uniquely designed for neurotransmitter recycling at inhibitory glycinergic synapses, and loss of GlyT2 function generates a severely hyperexcited state.

GlyT 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-10809
    Bitopertin Inhibitor 99.75%
    Bitopertin 是一种有效的非竞争性glycine reuptake 抑制剂,抑制甘氨酸摄取,IC50 为 25 nM。
  • HY-100416A
    LY2365109 hydrochloride Inhibitor 99.32%
    LY2365109是一个强的和选择性的GlyT1抑制剂,IC50是15.8 nM。
  • HY-101037
    Sarcosine Inhibitor
    Sarcosine 1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂。
  • HY-10809A
    Bitopertin R enantiomer Inhibitor
    Bitopertin R enantiomer (RG1678 R enantiomer; RO4917838 R enantiomer) 是 Bitopertin 的R型对映体。Bitopertin是非竞争性甘氨酸重吸收 (GlyT1) 抑制剂。
  • HY-107526
    NFPS Inhibitor
    NFPS 是一种选择性,非竞争性甘氨酸转运蛋白-1 (GlyT1) 抑制剂,对 hGlyT1 和 rGlyT1 的 IC50 分别为 2.8 nM 和 9.8 nM。NFPS 通过 glyR alpha1 亚基在瞬时局灶性脑缺血和再灌注的大鼠模型中发挥神经保护作用。
  • HY-111029
    ALX-1393 Inhibitor
    ALX-1393 是一种选择性 GlyT2 抑制剂, 对大鼠急性疼痛模型中的热,机械和化学刺激具有抗伤害作用。
  • HY-101334
    MPDC Inhibitor
    MPDC 是竞争性的、前脑突触体中的、Na+依赖的、高亲和力的谷氨酸转运体抑制剂。
  • HY-112432
    GlyT1 Inhibitor 1 Inhibitor
    GlyT1 Inhibitor 1 是一种有效的选择性 GlyT1 抑制剂,抑制 rGlyT1 IC50 为 38 nM。
  • HY-19887
    Tilapertin Inhibitor
    Tilapertin 是甘氨酸转运蛋白 1 型 (GlyT1) 的口服抑制剂。
Isoform Specific Products

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