1. 重组蛋白
  2. Viral Proteins
  3. Dengue Virus Proteins

Dengue Virus Proteins  (登革病毒)

Dengue virus (DENV) is an important human pathogen and contains four serotypes (DENV-1–4) which can be transmitted by mosquitos. The dengue viruses belongs to the genus Flavivirus in the family Flaviviridae. The dengue virus genome is a positive-sense, single stranded RNA with a size of 11 kb that contains one open reading frame. It is translated as a single, long polypeptide and then cut into ten proteins, including three structural (capsid [C], membrane [M], and envelope [E]) and seven nonstructural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) proteins. The nonstructural proteins play roles in viral replication and assembly. The structure of the dengue virus is roughly spherical, with a diameter of approximately 50 nm (1 nm is one millionth of 1 mm). The core of the virus is the nucleocapsid, a structure that is made of the viral genome along with C proteins. The nucleocapsid is surrounded by a membrane called the viral envelope, a lipid bilayer that is taken from the host. Embedded in the viral envelope are 180 copies of the E and M proteins that span through the lipid bilayer. These proteins form a protective outer layer that controls the entry of the virus into human cells.

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